Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019

被引：53

作者：

Winthrop, Kevin L. ^{[1
]}

Weinblatt, Michael E. ^{[2
]}

Bathon, Joan ^{[3
]}

Burmester, Gerd R. ^{[4
]}

Mease, Philip J. ^{[5
]}

Crofford, Leslie ^{[6
]}

Bykerk, Vivian ^{[7
]}

Dougados, Maxime ^{[8
]}

Rosenbaum, James Todd ^{[1
,9
]}

Mariette, Xavier ^{[10
]}

Sieper, Joachim ^{[11
]}

Melchers, Fritz ^{[12
]}

Cronstein, Bruce N. ^{[13
]}

Breedveld, Ferry C. ^{[14
]}

Kalden, Joachim ^{[15
]}

Smolen, Josef S. ^{[16
]}

Furst, Daniel ^{[5
,17
,18
]}

机构：

[1] Oregon Hlth & Sci Univ, Portland, OR 97239 USA

[2] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[3] Columbia Univ, Coll Phys & Surg, New York, NY USA

[4] Charite, Berlin, Germany

[5] Univ Washington, Swedish Med Ctr, Seattle, WA 98195 USA

[6] Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA

[7] Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA

[8] Hop Cochin, Paris, France

[9] Legacy Devers Eye Inst, Portland, OR USA

[10] Univ Paris Saclay, Paris Sud Univ, Hop Bicetre, AP HP, Le Kremlin Bicetre, France

[11] Charite, Campus Benjamin Franklin, Dept Gastroenterol Infect Dis & Rheumatol, Berlin, Germany

[12] Max Planck Inst Infect Biol, Berlin, Germany

[13] NYU, Sch Med, New York, NY USA

[14] Leiden Univ, Med Ctr, Leiden, Netherlands

[15] Univ Erlangen Nurnberg, Erlangen, Germany

[16] Med Univ Vienna, Dept Med 3, Div Rheumatol, Vienna, Austria

[17] Univ Calif Los Angeles, Med Ctr, Los Angeles, CA 90024 USA

[18] Univ Florence, Florence, Italy

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2020年 / 79卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; DOUBLE-BLIND; AMERICAN-COLLEGE; EULAR RECOMMENDATIONS; PSORIATIC-ARTHRITIS; CLINICAL-TRIALS; DISEASE; EFFICACY; SAFETY; STATE;

D O I：

10.1136/annrheumdis-2019-216151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To detail the greatest areas of unmet scientific and clinical needs in rheumatology. Methods The 21st annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of 5 disease-specific groups with 20-30 experts assigned to each group based on expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and other systemic autoimmune rheumatic diseases. In each group, experts were asked to identify unmet clinical and translational research needs in general and then to prioritise and detail the most important specific needs within each disease area. Results Overarching themes across all disease states included the need to innovate clinical trial design with emphasis on studying patients with refractory disease, the development of trials that take into account disease endotypes and patients with overlapping inflammatory diseases, the need to better understand the prevalence and incidence of inflammatory diseases in developing regions of the world and ultimately to develop therapies that can cure inflammatory autoimmune diseases. Conclusions Unmet needs for new therapies and trial designs, particularly for those with treatment refractory disease, remain a top priority in rheumatology.

引用

页码：88 / 93

页数：6

共 67 条

[41] Evaluation of the impact of concomitant fibromyalgia on TNF alpha blockers' effectiveness in axial spondyloarthritis: results of a prospective, multicentre study [J].