NEBULIZED TRANEXAMIC ACID FOR THE USE OF EPISTAXIS: A CASE REPORT

被引：4

作者：

Booth, Deborah Y. ^{[1
]}

Cruz, Joseph E. ^{[1
]}

Benson, Cynthia L. ^{[2
]}

机构：

[1] Atlantic Hlth Syst, Overlook Med Ctr, Dept Pharm, Summit, NJ USA

[2] Atlantic Hlth Syst, Overlook Med Ctr, Dept Emergency Med, Summit, NJ USA

来源：

JOURNAL OF EMERGENCY MEDICINE | 2020年 / 58卷 / 01期

关键词：

epistaxis; nebulized tranexamic acid; tranexamic acid;

D O I：

10.1016/j.jemermed.2019.10.030

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Tranexamic acid is an antifibrinolytic agent and functions as a competitive inhibitor of plasminogen activation, promoting hemostasis. Topical application of tranexamic acid for the control of epistaxis has been described in the literature, mainly through administration with gauze and packing. There is limited evidence for the use of tranexamic acid via alternative routes of administration such as nebulization. Case Report: We describe a patient who presented to the emergency department with epistaxis who was treated with nebulized tranexamic acid. Why Should an Emergency Physician Be Aware of This?: Our case provides an alternative treatment modality using nebulizing tranexamic acid to help manage epistaxis in patients that cannot bemanaged with topical antifibrinolytic therapy administered by other means. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：110 / 112

页数：3

共 8 条

[1]

Hassen GW, 2018, AM J EMERG MED, V36

[2] HEMOPTYSIS? TRY INHALED TRANEXAMIC ACID [J].

Komura, Stephanie ;

Rodriguez, Robert M. ;

Peabody, Christopher R. .

JOURNAL OF EMERGENCY MEDICINE, 2018, 54 (05) :E97-E99

[3] Tranexamic acid in epistaxis: who bloody nose? [J].

Penrose, Nicola ;

May, Gabby .

EMERGENCY MEDICINE JOURNAL, 2016, 33 (11) :823-825

[4] Inhaled Tranexamic Acid as an Alternative for Hemoptysis Treatment [J].

Segrelles Calvo, Gonzalo ;

De Granda-Orive, Ignacio ;

Lopez Padilla, Daniel .

CHEST, 2016, 149 (02) :604-604

[5] Pulmonary hemorrhage: A novel mode of therapy [J].

Solomonov, Anna ;

Fruchter, Oren ;

Zuckerman, Tzila ;

Brenner, Benjamin ;

Yigla, Mordechai .

RESPIRATORY MEDICINE, 2009, 103 (08) :1196-1200

[6] Inhaled Tranexamic Acid for Hemoptysis Treatment A Randomized Controlled Trial [J].

Wand, Ori ;

Guber, Elad ;

Guber, Alexander ;

Shochet, Gali Epstein ;

Israeli-Shani, Lilach ;

Shitrit, David .

CHEST, 2018, 154 (06) :1379-1384

[7] Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia A Randomized Clinical Trial [J].

Whitehead, Kevin J. ;

Sautter, Nathan B. ;

McWilliams, Justin P. ;

Chakinala, Murali M. ;

Merlo, Christian A. ;

Johnson, Maribeth H. ;

James, Melissa ;

Everett, Eric M. ;

Clancy, Marianne S. ;

Faughnan, Marie E. ;

Oh, S. Paul ;

Olitsky, Scott E. ;

Pyeritz, Reed E. ;

Gossage, James R. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 316 (09) :943-951

[8] A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial [J].

Zahed, Reza ;

Moharamzadeh, Payman ;

AlizadehArasi, Saeid ;

Ghasemi, Asghar ;

Saeedi, Morteza .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2013, 31 (09) :1389-1392

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