Rhodium(III)-Catalyzed Synthesis of Quinazolin-4(3H)-ones with N-Methoxyamides as Synthesis Reagents

被引：4

作者：

Zhou, Guanyu ^{[1
]}

Huang, Zhibin ^{[1
]}

Xu, Xu ^{[1
]}

Fang, Zhang ^{[1
]}

Huang, Pengcheng ^{[1
]}

Deng, Zefeng ^{[1
]}

Li, Bao ^{[2
]}

Zhao, Yingsheng ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 14期

关键词：

rhodium; quinazolin-4(3H)-one; C-H activation; cyclization; N-methoxyamide; ONE-POT SYNTHESIS; ACTIVATION; ANNULATION; ACID; QUINAZOLINONES; BENZAMIDES; CLEAVAGE;

D O I：

10.1055/a-1792-9930

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical method to synthesize quinoxalinones via intra/intermolecular amination using rhodium as the catalyst was developed. A wide variety of quinoxalinones were prepared from N-methoxybenzamides in moderate to excellent yields. Gram-scale reactions were also achieved, highlighting the synthetic importance of this new transformation.

引用

页码：3298 / 3306

页数：9

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