Treatment of multiple evanescent white dot syndrome with cyclosporine

PURPOSE. To report the seven-year follow-up of a patient with multiple evanescent white-dot syndrome (MEWDS). METHODS. Case report: A 46-year-old woman presented recurrent episodes of bilateral MEWDS. RESULTS. During the seven-year follow-up there were nine episodes of MEWDS. After four bouts in the first two, cyclosporine therapy was started. During two years of treatment there were no recurrences except when the dose was reduced or discontinued. CONCLUSIONS. The etiology of MEWDS is still unknown but the absence of new episodes during cyclosporine treatment and the recurrence immediately after decreasing or discontinuing the drug suggests an autoimmune origin, with the involvement of cellular immunity in the pathogenic process.