Fronto-parietal Cortical Circuits Encode Accumulated Evidence with a Diversity of Timescales

被引:92
作者
Scott, Benjamin B. [1 ,2 ]
Constantinople, Christine M. [1 ,2 ]
Akrami, Athena [1 ,2 ,3 ]
Hanks, Timothy D. [5 ,6 ]
Brody, Carlos D. [1 ,2 ,3 ]
Tank, David W. [1 ,2 ,4 ]
机构
[1] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA
[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
[3] Princeton Univ, Howard Hughes Med Inst, Princeton, NJ 08544 USA
[4] Princeton Univ, Bezos Ctr Neural Circuit Dynam, Princeton, NJ 08544 USA
[5] Univ Calif Davis, Ctr Neurosci, Davis, CA 95618 USA
[6] Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA
关键词
LATERAL INTRAPARIETAL AREA; POSTERIOR PARIETAL CORTEX; PREFRONTAL CORTEX; CELLULAR RESOLUTION; WORKING-MEMORY; DECISION-MAKING; NEURAL ACTIVITY; VISUAL-CORTEX; NEURONS; MODELS;
D O I
10.1016/j.neuron.2017.06.013
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Decision-making in dynamic environments often involves accumulation of evidence, in which new information is used to update beliefs and select future actions. Using in vivo cellular resolution imaging in voluntarily head-restrained rats, we examined the responses of neurons in frontal and parietal cortices during a pulse-based accumulation of evidence task. Neurons exhibited activity that predicted the animal's upcoming choice, previous choice, and graded responses that reflected the strength of the accumulated evidence. The pulsatile nature of the stimuli enabled characterization of the responses of neurons to a single quantum (pulse) of evidence. Across the population, individual neurons displayed extensive heterogeneity in the dynamics of responses to pulses. The diversity of responses was sufficiently rich to form a temporal basis for accumulated evidence estimated from a latent variable model. These results suggest that heterogeneous, often transient sensory responses distributed across the fronto-parietal cortex may support working memory on behavioral timescales.
引用
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页码:385 / +
页数:19
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