Long non-coding RNAs as novel therapeutic targets in cancer

被引：75

作者：

Lavorgna, Giovanni ^{[1
]}

Vago, Riccardo ^{[1
,2
]}

Sarmini, Mohamad ^{[1
]}

Montorsi, Francesco ^{[1
,2
]}

Salonia, Andrea ^{[1
,2
]}

Bellone, Matteo ^{[3
]}

机构：

[1] Osped San Raffaele, URI, Div Oncol, Unit Urol,IRCCS, Via Olgettina 60, I-20132 Milan, Italy

[2] Univ Vita Salute San Raffaele, I-20132 Milan, Italy

[3] Ist Sci San Raffaele, Cellular Immunol Unit, Milan, Italy

来源：

PHARMACOLOGICAL RESEARCH | 2016年 / 110卷

关键词：

ncRNA; Cancer; Bioinformatics; Drug delivery; Apoptosis; SMALL INTERFERING RNA; SEARCHING BLAST OUTPUT; ANTISENSE TRANSCRIPTION; PROGNOSTIC MARKER; CELL; GENOME; EVOLUTION; DELIVERY; LNCRNA; DNA;

D O I：

10.1016/j.phrs.2016.05.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thanks to impressive technology advancements, pervasive expression of non-coding RNAs (ncRNAs) has been recently identified in the genome of numerous cancers. Long ncRNAs (IncRNAs) belong to a new class of ncRNAs including tens of thousands different species. A fraction of these molecules shows a striking cancer-enriched expression pattern, suggesting an essential role in tumor cells and, possibly, a utility in therapeutic terms. This review aims at summarizing current knowledge for the identification and validation of IncRNAs as therapeutics targets in tumors. Both in-silico and wet-biology resources are presented in relation to the many challenges that the scientific community still needs to address in terms of IncRNA identification, stratification, patient personalization, drug delivery and toxicity. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：131 / 138

页数：8

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