Lack of Shunt Response in Suspected Idiopathic Normal Pressure Hydrocephalus with Alzheimer Disease Pathology

被引：141

作者：

Hamilton, Roy ^{[1
,2
]}

Patel, Sunil ^{[1
]}

Lee, Edward B. ^{[3
,4
]}

Jackson, Eric M. ^{[5
]}

Lopinto, Joanna ^{[5
]}

Arnold, Steven E. ^{[2
]}

Clark, Christopher M. ^{[2
]}

Basil, Anuj

Shaw, Leslie M. ^{[3
,4
]}

Xie, Sharon X. ^{[6
]}

Grady, M. Sean ^{[5
]}

Trojanowski, John Q. ^{[3
,4
]}

机构：

[1] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[2] Univ Penn, Penn Memory Ctr, Philadelphia, PA 19104 USA

[3] Univ Penn, Inst Aging, Philadelphia, PA 19104 USA

[4] Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA

[6] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

来源：

ANNALS OF NEUROLOGY | 2010年 / 68卷 / 04期

关键词：

COMORBIDITY;

D O I：

10.1002/ana.22015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine the impact of cortical Alzheimer disease pathology on shunt responsiveness in individuals treated for idiopathic normal pressure hydrocephalus (iNPH), 37 patients clinically diagnosed with iNPH participated in a prospective study in which performance on neurologic, psychometric, and gait measures before and 4 months after shunting was correlated with amyloid plaques, neuritic plaques, and neurofibrillary tangles observed in cortical biopsies obtained during shunt insertion. No complications resulted from biopsy acquisition. Moderate to severe pathology was associated with worse baseline cognitive performance and diminished postoperative improvement on NPH symptom severity scales, gait measures, and cognitive instruments compared to patients lacking pathology. ANN NEUROL 2010;68:535-540

引用

页码：535 / 540

页数：6

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