New biologically active epidioxysterols from Stereum hirsutum

被引：33

作者：

Cateni, Francesca

Doljak, Bojan

Zacchigna, Marina

Anderluh, Marko

Piltaver, Andrej

Scialino, Giuditta

Banfi, Elena

机构：

[1] Univ Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy

[2] Univ Ljubljana, Fac Pharm, Dept Pharmaceut Biol, Ljubljana, Slovenia

[3] Univ Ljubljana, Fac Pharm, Dept Pharmaceut Chem, Ljubljana, Slovenia

[4] Inst Syst Higher Fungi, Ljubljana, Slovenia

[5] Univ Trieste, Dept Biomed Sci, Microbiol Sect, I-34127 Trieste, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 22期

关键词：

Stereum hirsutum; epidioxysterols; Mycobacterium tuberculosis; antitubercular activity;

D O I：

10.1016/j.bmcl.2007.08.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

From the fungus Stereum hirsutum have been isolated and identified two new epidioxysterols 1, 4, together with two known ones 2 and 3. Their structures were elucidated on the basis of spectroscopic analysis and chemical reactions. Epidioxysterols 1-4 have been shown to possess a significant activity against Mycobacterium tuberculosis. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6330 / 6334

页数：5

共 15 条

[1] Isolation and bioactivities of epidioxysterol from the tunicate Cynthia savignyi [J].