A convenient new synthesis of fused 1,2,4-triazoles:: the oxidation of heterocyclic hydrazones using copper dichloride

被引：68

作者：

Ciesielski, M ^{[1
]}

Pufky, D ^{[1
]}

Döring, M ^{[1
]}

机构：

[1] Forschungszentrum Karslruhe, Inst Tech Chem, D-76021 Karlsruhe, Germany

来源：

TETRAHEDRON | 2005年 / 61卷 / 24期

关键词：

oxidation; copper; hydrazones; 1,2,4-triazoles;

D O I：

10.1016/j.tet.2005.01.111

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 1,2,4-triazoles have been prepared by oxidative intramolecular cyclization of heterocyclic hydrazones with copper dichloride. General applicability of this simple transformation was confirmed by the synthesis of moderate to high yields of 1,2,4-triazolo[4,3-a]pyridines, 1,2,4-triazolo[4,3-a]pyrimidines, 1,2,4-triazolo[4,3-b]pyridazines, 1,2,4-triazolo[4,3-a]phthalazines, and 1,2,4-triazolo[4,3-a]quinoxalines. A 1,2,4-triazolo[4,3-e]purine-6,8(7H)-dione was obtained in a lower yield. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5942 / 5947

页数：6

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