X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

被引：305

作者：

Montay-Gruel, Pierre ^{[1
]}

Bouchet, Audrey ^{[2
]}

Jaccard, Maud ^{[3
]}

Patin, David ^{[3
]}

Serduc, Raphael ^{[2
]}

Aim, Warren ^{[2
]}

Petersson, Kristoffer ^{[1
,3
]}

Petit, Benoit ^{[1
]}

Bailat, Claude ^{[3
]}

Bourhis, Jean ^{[1
]}

Brauer-Krisch, Elke ^{[4
]}

Vozenin, Marie-Catherine ^{[1
]}

机构：

[1] CHU Vaudois, Lausanne Univ Hosp, Dept Radiat Oncol DO Radiooncol, Lausanne, Switzerland

[2] Univ Grenoble Alpes, Rayonnement Synchrotron & Rech Med, F-38000 Grenoble, France

[3] Lausanne Univ Hosp, Inst Radiat Phys IRA, Lausanne, Switzerland

[4] ESRF, Grenoble, France

来源：

RADIOTHERAPY AND ONCOLOGY | 2018年 / 129卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

Ultra-high dose-rate X-ray radiation; Synchrotron radiation; Cognitive impairment; Radiation-induced brain injury; RADIATION-THERAPY; ADJUVANT TEMOZOLOMIDE; COGNITIVE DEFICITS; RADIOTHERAPY; CELLS; CONCOMITANT; MANAGEMENT;

D O I：

10.1016/j.radonc.2018.08.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis. (C) 2018 Published by Elsevier B.V.

引用

页码：582 / 588

页数：7

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