Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk-Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery

被引：51
|
作者：
Li, Guilan [1 ]
Chen, Yidan [1 ]
Zhang, Lingyu [1 ]
Zhang, Manjie [1 ]
Li, Shengnan [1 ]
Li, Lu [1 ]
Wang, Tingting [2 ]
Wang, Chungang [1 ]
机构：
[1] Northeast Normal Univ, Fac Chem, Changchun 130024, Jilin, Peoples R China
[2] Changchun Univ Sci & Technol, Sch Chem & Environm Engn, Changchun 130022, Jilin, Peoples R China
来源：
NANO-MICRO LETTERS | 2018年 / 10卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Yolk-shell structure; Calcium phosphate; Dual-mode imaging; Photothermal therapy; Drug delivery; CHEMO-PHOTOTHERMAL THERAPY; IN-VIVO; MAGNETIC-RESONANCE; BREAST-CANCER; CALCIUM; RELEASE; TUMOR; CHEMOTHERAPY; NANOSPHERES; DIAGNOSIS;
D O I：
10.1007/s40820-017-0155-3
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate (AuNR@PAA/CaP) yolk-shell nanoparticles (NPs) composed with a PAA/CaP shell and an AuNR yolk is reported. The asobtained AuNR@PAA/CaP yolk-shell NPs possess ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs), superior photothermal conversion property (26%) and pH/near-infrared (NIR) dual-responsive drug delivery performance. The released DOX continuously increased due to the damage of the CaP shell at low pH values. When the DOX-loaded AuNR@PAA/CaP yolk-shell NPs were exposed to NIR irradiation, a burst-like drug release occurs owing to the heat produced by the AuNRs. Furthermore, AuNR@PAA/CaPyolk-shell NPs are successfully employed for synergic dual-mode X-ray computed tomography/photoacoustic imaging and chemo-photothermal cancer therapy. Therefore, this work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.
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页码：1 / 11
页数：11
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