Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization

被引：156
|
作者：
Bruschi, ML
Cardoso, MLC
Lucchesi, MB
Gremiao, MPD [1 ]
机构：
[1] UNESP, Programa Pos Grad Ciencias Farmaceut, BR-14802902 Araraquara, SP, Brazil
[2] Univ Estadual Maringa, Dept Farmacia & Farmacol, BR-87020900 Maringa, Parana, Brazil
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2003年 / 264卷 / 1-2期
关键词：
propolis; gelatin; spray-drying; microparticle characterization; optimization;
D O I：
10.1016/S0378-5173(03)00386-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gelatin microparticles containing propolis extractive solution (PES) were prepared by spray-drying technique. The optimization of the spray-drying operating conditions and the proportions of gelatin and mannitol were investigated. Regular particle morphology was obtained when mannitol was used, whereas mannitol absence produced a substantial number of coalesced and agglomerated microparticles. Microparticles had a mean diameter of 2.70 mum without mannitol and 2.50 mum with mannitol. The entrapment efficiency for propolis of the microparticles was upto 41 % without mannitol and 39% with mannitol. The microencapsulation by spray-drying technique maintained the activity of propolis against Staphylococcus aureus. These gelatin microparticles containing propolis would be useful for developing intermediary or eventual propolis dosage form without the PES' strong and unpleasant taste, aromatic odour, and presence of ethanol. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：45 / 55
页数：11
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