Eco-friendly synthesis of phthalate angico gum towards nanoparticles engineering using Quality by Design (QbD) approach

被引：13

作者：

de Oliveira, Thaisa Cardoso ^{[1
]}

de Jesus Oliveira, Antonia Carla ^{[1
]}

Gomes Patriota, Yuri Basilio ^{[1
]}

Chaves, Luise Lopes ^{[1
]}

Silva Ribeiro, Fabio de Oliveira ^{[2
]}

de Paula, Regina C. M. ^{[3
]}

Silva-Filho, Edson Cavalcanti ^{[4
]}

da Silva, Durcilene Alves ^{[2
]}

de La Roca Soares, Monica Felts ^{[1
]}

Soares-Sobrinho, Jose Lamartine ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Pharmaceut Sci, Recife, PE, Brazil

[2] Fed Univ Delta Parnaiba, Res Ctr Biodivers & Biotechnol BIOTEC, Parnaiba, PI, Brazil

[3] Univ Fed Ceara, Dept Organ & Inorgan Chem, Fortaleza, Ceara, Brazil

[4] Univ Fed Piaui, Interdisciplinary Lab Adv Mat LIMAV, Teresina, PI, Brazil

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 190卷

关键词：

Nanoparticles; Biopolymer; Quality by Design; Plackett-Burman design; Anadenanthera colubrina; CASHEW GUM; ORAL DELIVERY; OPTIMIZATION; FORMULATION; VARIABLES; EXUDATE; HETEROPOLYSACCHARIDE; OLIGOSACCHARIDES; CLOFAZIMINE; MECHANISM;

D O I：

10.1016/j.ijbiomac.2021.09.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We developed a new hydrophobic polymer based on angico gum (AG), and we produced new nanoparticles to expand the applications of natural polysaccharides in nanomedicine. Phthalate angico gum (PAG) was charac-terized by H-1 NMR, FTIR, elementary analysis, solubility, XRD, and TG. PAG was a hydrophobic and semi-crystalline material, a relevant characteristic for drug delivery system applications. As a proof of concept, ne-virapine (NVP) was selected for nanoparticles development. Plackett-Burman's experimental design was used to understand the influence of several factors in nanoparticles production. PAG proved to be a versatile material for producing nanoparticles with different characteristics. Optimized nanoparticles were produced using desirability parameters. NVP-loaded PAG nanoparticles formulation showed 202.1 nm of particle size, 0.23 of PDI,-17.1 of zeta potential, 69.8 of encapsulation efficiency, and promoted modified drug release for 8 h. Here we show that PAG presents as a promising biopolymer for drug delivery systems.

引用

页码：801 / 809

页数：9