Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions

被引：12

作者：

Shaposhnikov, Mikhail, V ^{[1
]}

Guvatova, Zulfiya G. ^{[2
]}

Zemskaya, Nadezhda, V ^{[1
]}

Koval, Liubov A. ^{[1
]}

Schegoleva, Eugenia, V ^{[1
]}

Gorbunova, Anastasia A. ^{[1
]}

Golubev, Denis A. ^{[1
]}

Pakshina, Natalya R. ^{[1
]}

Ulyasheva, Natalia S. ^{[1
]}

Solovev, Ilya A. ^{[1
]}

Bobrovskikh, Margarita A. ^{[3
]}

Gruntenko, Nataly E. ^{[3
]}

Menshanov, Petr N. ^{[4
,5
]}

Krasnov, George S. ^{[2
]}

Kudryavseva, Anna, V ^{[2
]}

Moskalev, Alexey A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Ural Branch, Lab Geroprotect & Radioprotect Technol, Inst Biol,Komi Sci Ctr, Syktyvkar 167982, Russia

[2] Russian Acad Sci, Engelhardt Inst Mol Biol, Ctr Precis Genome Editing & Genet Technol Biomed, Moscow 119991, Russia

[3] Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Lab Stress Genet, Lavrentiev Ave 10, Novosibirsk 630090, Russia

[4] Novosibirsk State Univ, Physiol Dept, Pirogova 1, Novosibirsk 630090, Russia

[5] Novosibirsk State Tech Univ, Laser Syst Dept, Karl Marx Ave 20, Novosibirsk 630073, Russia

来源：

COMMUNICATIONS BIOLOGY | 2022年 / 5卷 / 01期

关键词：

GENE-EXPRESSION; CALORIE RESTRICTION; STRESS-RESISTANCE; BODY-TEMPERATURE; DOWN-REGULATION; TOTAL LIPIDS; AUTOPHAGY; TOR; PACKAGE; MODULATION;

D O I：

10.1038/s42003-022-03524-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The lifespan of fruit flies can be extended up to 213 days under specialized conditions. Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w(1118) strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.

引用

页数：15

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