Influence of dietary protein on Dahl salt-sensitive hypertension: a potential role for gut microbiota

被引:12
作者
Abais-Battad, Justine M. [1 ]
Mattson, David L. [1 ]
机构
[1] Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA
基金
美国国家卫生研究院;
关键词
blood pressure; dietary interventions; microbiome; LIPOPOLYSACCHARIDE-BINDING PROTEIN; TRIMETHYLAMINE-N-OXIDE; CHAIN FATTY-ACIDS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; SODIUM SENSITIVITY; COUPLED RECEPTOR; RENAL-DISEASE; HIGH SUCROSE; IN-UTERO;
D O I
10.1152/ajpregu.00399.2017
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
High blood pressure affects 1.39 billion adults across the globe and is the leading preventable cause of death worldwide. Hypertension is a multifaceted disease with known genetic and environmental factors contributing to its progression. Our studies utilizing the Dahl salt-sensitive (SS) rat have demonstrated the remarkable influence of dietary protein and maternal environment on the development of hypertension and renal damage in response to high salt. There is growing interest in the relationship between the microbiome and hypertension, with gut dysbiosis being correlated to a number of pathologies. This review summarizes the current literature regarding the interplay among dietary protein, the gut microbiota, and hypertension. These studies may provide insight into the effects we have observed between diet and hypertension in Dahl SS rats and, we hope, lead to new perspectives where potential dietary interventions or microbiota manipulations could serve as plausible therapies for hypertension.
引用
收藏
页码:R907 / R914
页数:8
相关论文
共 122 条
  • [1] The Placenta Harbors a Unique Microbiome
    Aagaard, Kjersti
    Ma, Jun
    Antony, Kathleen M.
    Ganu, Radhika
    Petrosino, Joseph
    Versalovic, James
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (237)
  • [2] Rag1-null Dahl SS rats reveal that adaptive immune mechanisms exacerbate high protein-induced hypertension and renal injury
    Abais-Battad, Justine M.
    Lund, Hayley
    Fehrenbach, Daniel J.
    Dasinger, John Henry
    Mattson, David L.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2018, 315 (01) : R28 - R35
  • [3] Alterations in the gut microbiota can elicit hypertension in rats
    Adnan, Sareema
    Nelson, James W.
    Ajami, Nadim J.
    Venna, Venugopal R.
    Petrosino, Joseph F.
    Bryan, Robert M., Jr.
    Durgan, David J.
    [J]. PHYSIOLOGICAL GENOMICS, 2017, 49 (02) : 96 - 104
  • [4] The Microbiome and Blood Pressure: Can Microbes Regulate Our Blood Pressure?
    Al Khodor, Souhaila
    Reichert, Bernd
    Shatat, Ibrahim F.
    [J]. FRONTIERS IN PEDIATRICS, 2017, 5
  • [5] Dietary Protein and Blood Pressure: A Systematic Review
    Altorf-van der Kuil, Wieke
    Engberink, Marielle F.
    Brink, Elizabeth J.
    van Baak, Marleen A.
    Bakker, Stephan J. L.
    Navis, Gerjan
    van't Veer, Pieter
    Geleijnse, Johanna M.
    [J]. PLOS ONE, 2010, 5 (08):
  • [6] A clinical trial of the effects of dietary patterns on blood pressure
    Appel, LJ
    Moore, TJ
    Obarzanek, E
    Vollmer, WM
    Svetkey, LP
    Sacks, FM
    Bray, GA
    Vogt, TM
    Cutler, JA
    Windhauser, MM
    Lin, PH
    Karanja, N
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (16) : 1117 - 1124
  • [7] Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids - Results of the OmniHeart randomized trial
    Appel, LJ
    Sacks, FM
    Carey, VJ
    Obarzanek, E
    Swain, JF
    Miller, ER
    Conlin, PR
    Erlinger, TP
    Rosner, BA
    Laranjo, NM
    Charleston, J
    McCarron, P
    Bishop, LM
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (19): : 2455 - 2464
  • [8] FETAL NUTRITION AND CARDIOVASCULAR-DISEASE IN ADULT LIFE
    BARKER, DJP
    GLUCKMAN, PD
    GODFREY, KM
    HARDING, JE
    OWENS, JA
    ROBINSON, JS
    [J]. LANCET, 1993, 341 (8850) : 938 - 941
  • [9] FETAL AND PLACENTAL SIZE AND RISK OF HYPERTENSION IN ADULT LIFE
    BARKER, DJP
    BULL, AR
    OSMOND, C
    SIMMONDS, SJ
    [J]. BRITISH MEDICAL JOURNAL, 1990, 301 (6746) : 259 - 262
  • [10] MICROALBUMINURIA IN SALT-SENSITIVE PATIENTS - A MARKER FOR RENAL AND CARDIOVASCULAR RISK-FACTORS
    BIGAZZI, R
    BIANCHI, S
    BALDARI, D
    SGHERRI, G
    BALDARI, G
    CAMPESE, VM
    [J]. HYPERTENSION, 1994, 23 (02) : 195 - 199