Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication

被引：5

作者：

Gordon, Claire L. ^{[1
,2
]}

Smibert, Olivia C. ^{[1
,3
,4
]}

Holmes, Natasha E. ^{[1
,5
,6
]}

Chua, Kyra Y. L. ^{[1
]}

Rose, Morgan ^{[1
]}

Drewett, George ^{[1
]}

James, Fiona ^{[1
]}

Mouhtouris, Effie ^{[1
]}

Nguyen, Thi H. O. ^{[2
]}

Zhang, Wuji ^{[2
]}

Kedzierski, Lukasz ^{[2
,7
]}

Rowntree, Louise C. ^{[2
]}

Chua, Brendon Y. ^{[2
]}

Caly, Leon ^{[8
]}

Catton, Mike G. ^{[8
]}

Druce, Julian ^{[8
]}

Sait, Michelle ^{[9
]}

Seemann, Torsten ^{[9
]}

Sherry, Norelle L. ^{[1
,9
]}

Howden, Benjamin P. ^{[1
,9
]}

Kedzierska, Katherine ^{[2
]}

Kwong, Jason C. ^{[1
,2
]}

Trubiano, Jason A. ^{[1
,3
,4
,10
,11
]}

机构：

[1] Austin Hosp, Dept Infect Dis, Heidelberg, Vic, Australia

[2] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[3] Peter MacCallum Canc Ctr, Dept Infect Dis, Melbourne, Vic, Australia

[4] Peter MacCallum Canc Ctr, Natl Ctr Infect Canc, Melbourne, Vic, Australia

[5] Austin Hlth, Data Analyt Res & Evaluat Ctr, Heidelberg, Vic, Australia

[6] Univ Melbourne, Heidelberg, Vic, Australia

[7] Univ Melbourne, Fac Vet & Agr Sci, Melbourne, Vic, Australia

[8] Peter Doherty Inst Infect & Immun, Victorian Infect Dis Reference Lab, Riryal Melbourne Hosp, Melbourne, Vic, Australia

[9] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Publ Hlth Lab,Microbiol Diagnost Unit, Melbourne, Vic, Australia

[10] Austin Hlth, Dept Infect Dis, Ctr Antibiot Allergy & Res, Heidelberg, Vic, Australia

[11] Univ Melbourne, Dept Med, Austin Hlth, Heidelberg, Vic, Australia

来源：

OPEN FORUM INFECTIOUS DISEASES | 2021年 / 8卷 / 09期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

cellular immunity; COVID-19; humoral immunity; immunocompromise; lymphoma; SARS-CoV-2;

D O I：

10.1093/ofid/ofab359

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR+/CD38(+) activation, interleukin 6, and interleukin 18 in the absence of B cells and PD-1 expression was observed. SARS-CoV-2-specific antibody responses were absent and SARS-CoV-2-specific T cells were minimally detected. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.

引用

页数：5

共 15 条

[1] Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer [J].

Avanzato, Victoria A. ;

Matson, M. Jeremiah ;

Seifert, Stephanie N. ;

Pryce, Rhys ;

Williamson, Brandi N. ;

Anzick, Sarah L. ;

Barbian, Kent ;

Judson, Seth D. ;

Fischer, Elizabeth R. ;

Martens, Craig ;

Bowden, Thomas A. ;

de Wit, Emmie ;

Riedo, Francis X. ;

Munster, Vincent J. .

CELL, 2020, 183 (07) :1901-+

[2] Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient [J].

Baang, Ji Hoon ;

Smith, Christopher ;

Mirabelli, Carmen ;

Valesano, Andrew L. ;

Manthei, David M. ;

Bachman, Michael A. ;

Wobus, Christiane E. ;

Adams, Michael ;

Washer, Laraine ;

Martin, Emily T. ;

Lauring, Adam S. .

JOURNAL OF INFECTIOUS DISEASES, 2021, 223 (01) :23-27

[3] Restoring function in exhausted CD8 T cells during chronic viral infection [J].

Barber, DL ;

Wherry, EJ ;

Masopust, D ;

Zhu, BG ;

Allison, JP ;

Sharpe, AH ;

Freeman, GJ ;

Ahmed, R .

NATURE, 2006, 439 (7077) :682-687

[4] Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report [J].

Buckland, Matthew S. ;

Galloway, James B. ;

Fhogartaigh, Caoimhe Nic ;

Meredith, Luke ;

Provine, Nicholas M. ;

Bloor, Stuart ;

Ogbe, Ane ;

Zelek, Wioleta M. ;

Smielewska, Anna ;

Yakovleva, Anna ;

Mann, Tiffeney ;

Bergamaschi, Laura ;

Turner, Lorinda ;

Mescia, Frederica ;

Toonen, Erik J. M. ;

Hackstein, Carl-Philipp ;

Akther, Hossain Delowar ;

Vieira, Vinicius Adriano ;

Ceron-Gutierrez, Lourdes ;

Periselneris, Jimstan ;

Kiani-Alikhan, Sorena ;

Grigoriadou, Sofia ;

Vaghela, Devan ;

Lear, Sara E. ;

Torok, M. Estee ;

Hamilton, William L. ;

Stockton, Joanne ;

Quick, Josh ;

Nelson, Peter ;

Hunter, Michael ;

Coulter, Tanya I. ;

Devlin, Lisa ;

Bradley, John R. ;

Smith, Kenneth G. C. ;

Ouwehand, Willem H. ;

Estcourt, Lise ;

Harvala, Heli ;

Roberts, David J. ;

Wilkinson, Ian B. ;

Screaton, Nick ;

Loman, Nicholas ;

Doffinger, Rainer ;

Lyons, Paul A. ;

Morgan, B. Paul ;

Goodfellow, Ian G. ;

Klenerman, Paul ;

Lehner, Paul J. ;

Matheson, Nicholas J. ;

Thaventhiran, James E. D. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[5] The Role of Immunological and Clinical Biomarkers to Predict Clinical COVID-19 Severity and Response to Therapy-A Prospective Longitudinal Study [J].

Copaescu, Ana ;

James, Fiona ;

Mouhtouris, Effie ;

Vogrin, Sara ;

Smibert, Olivia C. ;

Gordon, Claire L. ;

Drewett, George ;

Holmes, Natasha E. ;

Trubiano, Jason A. .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[6] Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals [J].

Grifoni, Alba ;

Weiskopf, Daniela ;

Ramirez, Sydney, I ;

Mateus, Jose ;

Dan, Jennifer M. ;

Moderbacher, Carolyn Rydyznski ;

Rawlings, Stephen A. ;

Sutherland, Aaron ;

Premkumar, Lakshmanane ;

Jadi, Ramesh S. ;

Marrama, Daniel ;

de Silva, Aravinda M. ;

Frazier, April ;

Carlin, Aaron F. ;

Greenbaum, Jason A. ;

Peters, Bjoern ;

Krammer, Florian ;

Smith, Davey M. ;

Crotty, Shane ;

Sette, Alessandro .

CELL, 2020, 181 (07) :1489-+

[7] Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype [J].

Habel, Jennifer R. ;

Nguyen, Thi H. O. ;

van de Sandt, Carolien E. ;

Juno, Jennifer A. ;

Chaurasia, Priyanka ;

Wragg, Kathleen ;

Koutsakos, Marios ;

Hensen, Luca ;

Jia, Xiaoxiao ;

Chua, Brendon ;

Zhang, Wuji ;

Tan, Hyon-Xhi ;

Flanagan, Katie L. ;

Doolan, Denise L. ;

Torresi, Joseph ;

Chen, Weisan ;

Wakim, Linda M. ;

Cheng, Allen C. ;

Doherty, Peter C. ;

Petersen, Jan ;

Rossjohn, Jamie ;

Wheatley, Adam K. ;

Kent, Stephen J. ;

Rowntree, Louise C. ;

Kedzierska, Katherine .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (39) :24384-24391

[8]

National Institutes of Health, 2020, COVID 19 TREATM GUID

[9] Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV [J].

Ou, Xiuyuan ;

Liu, Yan ;

Lei, Xiaobo ;

Li, Pei ;

Mi, Dan ;

Ren, Lili ;

Guo, Li ;

Guo, Ruixuan ;

Chen, Ting ;

Hu, Jiaxin ;

Xiang, Zichun ;

Mu, Zhixia ;

Chen, Xing ;

Chen, Jieyong ;

Hu, Keping ;

Jin, Qi ;

Wang, Jianwei ;

Qian, Zhaohui .

NATURE COMMUNICATIONS, 2020, 11 (01)

[10] Overcoming T cell exhaustion in infection and cancer [J].

Pauken, Kristen E. ;

Wherry, E. John .

TRENDS IN IMMUNOLOGY, 2015, 36 (04) :265-276

← 1 2 →