Scars or Regeneration?-Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses

被引：97

作者：

Jiang, Dongsheng ^{[1
]}

Rinkevich, Yuval ^{[1
]}

机构：

[1] Helmholtz Zentrum Munchen, Inst Lung Biol & Dis, Comprehens Pneumol Ctr, Max Lebsche Platz 31, D-81377 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 02期

基金：

欧洲研究理事会;

关键词：

scarring; fibrosis; fibroblasts; regeneration; adhesion; HAIR FOLLICLE REGENERATION; GROWTH-FACTOR RECEPTOR; TISSUE REGENERATION; GRANULATION-TISSUE; HYPERTROPHIC SCARS; HIPPO PATHWAY; FACTOR-BETA; FIBROSIS; CELLS; EXPRESSION;

D O I：

10.3390/ijms21020617

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide an updated review on fibroblast heterogeneity as determinants of the scarring-regeneration continuum. We discuss fibroblast-centric mechanisms that dictate scarring-regeneration continua with a focus on intercellular and cell-matrix adhesion. Improved understanding of fibroblast lineage-specific mechanisms and how they determine scar severity will ultimately allow for the development of antiscarring therapies and the promotion of tissue regeneration.

引用

页数：16

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