Host and virus strain dependence in activation of human macrophages by human immunodeficiency virus type 1

被引:3
作者
Kazmierczak, Katarzyna [1 ]
Potash, Mary Jane [1 ]
机构
[1] Columbia Univ, St Lukes Roosevelt Hosp Ctr, Div Mol Virol, Med Ctr, New York, NY 10019 USA
关键词
aIDS dementia; HIV heterogeneity; host polymorphism; macrophage;
D O I
10.1080/13550280701510104
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Human immunodeficiency virus type 1 (HIV-1)-associated neuropathogenesis occurs in a large minority of infected people. Presently, there are neither viral nor cellular markers that predict the development of brain disease during HIV1 infection. This study was conducted to determine whether there exist systematic differences among human cell donors and virus strains for the activation of macrophage gene expression by HIV-1 that may contribute to neuropathogenesis. Four HIV-1, ADA and B-aL, which were isolated from peripheral tissues of acquired immunodeficiency syndrome (AIDS) patients, and DJV and YU-2, which were isolated from brains of patients with HIV-1-associated dementia, were compared for induction of expression of cellular genes associated with antiviral activity or inflammation in monocyte-derived macrophages from several donors. Virus replication and cytokine production were scored by enzyme-linked immunosorbent assay (ELISA) and cellular transcripts were measured by real-time polymerase chain reaction (PCR). ADA and B-aL, productively infected cells from all donors tested and induced all cellular transcripts tested, illustrating a common response of macrophages to HIV-1 replication. In sharp contrast, the viruses associated with neuropathogenesis, DJV and YU-2, induced intense gene expression early after infection in cells from a subset of donors but DJV did not productively infect these cells. No such heterogeneity was observed in the responses of macrophages during high-level replication of any HIV-1 tested. The susceptibility to early activation by HIV-1 may reflect susceptibility to neuropathogenesis in AIDS.
引用
收藏
页码:452 / 461
页数:10
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