In vitro-generated alloantigen-specific Th9 cells mediate antileukemia cytotoxicity in the absence of graft-versus-host disease

被引:7
作者
Reisser, Tanja [1 ]
Halbgebauer, Daniel [1 ]
Scheurer, Jasmin [1 ]
Wolf, Linda [1 ]
Leithaeuser, Frank [2 ]
Beyersdorf, Niklas [3 ]
Fischer-Posovszky, Pamela [1 ]
Debatin, Klaus-Michael [1 ]
Strauss, Gudrun [1 ]
机构
[1] Univ Med Ctr Ulm, Dept Pediat & Adolescent Med, Ulm, Germany
[2] Univ Ulm, Inst Pathol, Ulm, Germany
[3] Univ Wurzburg, Inst Virol & Immunobiol, Wurzburg, Germany
关键词
MHC CLASS-II; INTERLEUKIN-9;
D O I
10.1038/s41375-020-0731-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:1943 / 1948
页数:6
相关论文
共 15 条
[1]   Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression [J].
Chang, CH ;
Guerder, S ;
Hong, SC ;
vanEwijk, W ;
Flavell, RA .
IMMUNITY, 1996, 4 (02) :167-178
[2]   Induction of the IL-9 gene by HTLV-1 Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism [J].
Chen, Jing ;
Petrus, Mike ;
Bryant, Bonita R. ;
Nguyen, Vinh Phuc ;
Stamer, Mindy ;
Goldman, Carolyn K. ;
Bamford, Richard ;
Morris, John C. ;
Janik, John E. ;
Waldmann, Thomas A. .
BLOOD, 2008, 111 (10) :5163-5172
[3]  
Drénou B, 1999, J IMMUNOL, V163, P4115
[4]   Interleukin-9 in Stable Liver Transplant Recipients [J].
Fabrega, E. ;
Lopez-Hoyos, M. ;
San Segundo, D. ;
Casafont, F. ;
Moraleja, I. ;
Sampedro, B. ;
Pons-Romero, F. .
TRANSPLANTATION PROCEEDINGS, 2012, 44 (06) :1536-1538
[5]   Increased serum levels of interleukin-9 correlate to negative prognostic factors in Hodgkin's lymphoma [J].
Fischer, M ;
Bijman, M ;
Molin, D ;
Cormont, F ;
Uyttenhove, C ;
van Snick, J ;
Sundström, C ;
Enblad, G ;
Nilsson, G .
LEUKEMIA, 2003, 17 (12) :2513-2516
[6]   In vitro-established alloantigen-specific CD8+ CTLs mediate graft-versus-tumor activity in the absence of graft-versus-host disease [J].
Hartmann, N. ;
Leithaeuser, F. ;
Albers, C. ;
Duyster, J. ;
Moeller, P. ;
Debatin, K-M ;
Strauss, G. .
LEUKEMIA, 2011, 25 (05) :848-855
[7]   The development and in vivo function of T helper 9 cells [J].
Kaplan, Mark H. ;
Hufford, Matthew M. ;
Olson, Matthew R. .
NATURE REVIEWS IMMUNOLOGY, 2015, 15 (05) :295-307
[8]  
Le E, 2005, ANTICANCER RES, V25, P3889
[9]   Th9 cells promote antitumor immune responses in vivo [J].
Lu, Yong ;
Hong, Sungyoul ;
Li, Haiyan ;
Park, Jungsun ;
Hong, Bangxing ;
Wang, Lijuan ;
Zheng, Yuhuan ;
Liu, Zhiqiang ;
Xu, Jingda ;
He, Jin ;
Yang, Jing ;
Qian, Jianfei ;
Yi, Qing .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (11) :4160-4171
[10]   Rapamycin Resistant Murine Th9 Cells Have a Stable In Vivo Phenotype and Inhibit Graft-Versus-Host Reactivity [J].
Mangus, Courtney W. ;
Massey, Paul R. ;
Fowler, Daniel H. ;
Amarnath, Shoba .
PLOS ONE, 2013, 8 (08)