Immunotherapy coming of age: What will it take to make it standard of care for glioblastoma?

被引：76

作者：

Heimberger, Amy B. ^{[1
]}

Sampson, John H. ^{[2
,3
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

[2] Duke Univ, Med Ctr, Div Neurosurg, Dept Surg, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC USA

[4] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

来源：

NEURO-ONCOLOGY | 2011年 / 13卷 / 01期

关键词：

clinical trial; glioblastoma multiforme; immunotherapy; malignant gliomas; T-CELL RESPONSES; CENTRAL-NERVOUS-SYSTEM; RECOMBINANT INTERLEUKIN-2 THERAPY; AUTOLOGOUS TUMOR-CELLS; CERVICAL LYMPH-NODES; LONG-TERM SURVIVAL; METASTATIC MELANOMA; DENDRITIC CELLS; PEPTIDE VACCINATION; CEREBROSPINAL-FLUID;

D O I：

10.1093/neuonc/noq169

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the recent approval by the FDA of an immunotherapy for prostate cancer and another positive immunotherapy trial in melanoma, immunotherapy may finally be coming of age. So what will it take for it to become part of the standard treatment for glioblastoma? To put this question into perspective, we summarize critical background information in neuro-immunology, address immunotherapy clinical trial design, and discuss a number of extrinsic factors that will impact the development of immunotherapy in neuro-oncology.

引用

页码：3 / 13

页数：11

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