Chemotherapeutic potential of orally administered poly(lactide-co-glycolide) microparticles containing isoniazid, rifampin, and pyrazinamide against experimental tuberculosis

被引：36

作者：

ul-Ain, Q ^{[1
]}

Sharma, S ^{[1
]}

Khuller, GK ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Biochem, Chandigarh 160012, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 09期

关键词：

D O I：

10.1128/AAC.47.9.3005-3007.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Poly(lactide-co-glycolide) (PLG) microspheres (diameter, less than 3 mum) containing isoniazid, rifampin, and pyrazinamide were used in a sustained oral drug delivery system to treat murine tuberculosis. Drug levels above the MIC were observed up to 72 h in plasma and for 9 days in various organs. Relative bioavailability of encapsulated drugs was greater than that of free drugs. Chemotherapy results showed better or equivalent clearance of bacilli in the PLG-drug-administered group (weekly) than with free drugs (daily).

引用

页码：3005 / 3007

页数：3

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