Cobalt-Catalyzed Directed Alkylation of Olefinic C-H Bond with Primary and Secondary Alkyl Chlorides

被引：14

作者：

Yamakawa, Takeshi ^{[1
]}

Seto, Yuan Wah ^{[1
]}

Yoshikai, Naohiko ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

SYNLETT | 2015年 / 26卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

cobalt; C-H activation; alkylations; alkyl halides; alkenes; CROSS-COUPLING REACTIONS; ARYL GRIGNARD-REAGENTS; AROMATIC IMINES; HALIDES; IRON; ACTIVATION; CARBOXAMIDES; ARENES; FUNCTIONALIZATIONS; HYDROARYLATION;

D O I：

10.1055/s-0034-1379247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cobalt-N -heterocyclic carbene catalytic system promotes pyridine-directed olefinic C-H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt intermediate to the alkyl chloride

引用

页码：340 / 344

页数：5

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