5-HT6 MEDICINAL CHEMISTRY

被引:64
作者
Liu, Kevin G. [1 ]
Robichaud, Albert J. [1 ]
机构
[1] Lundbeck Res USA, Paramus, NJ 07652 USA
来源
PHARMACOLOGY OF 5-HT6 RECEPTORS, PT 1 | 2010年 / 94卷
关键词
ATYPICAL ANTIPSYCHOTIC AGENTS; SEROTONIN RECEPTOR-BINDING; BRAIN PENETRANT; ANTISENSE OLIGONUCLEOTIDES; BIOLOGICAL EVALUATION; ALZHEIMERS-DISEASE; H5-HT6; RECEPTORS; HIGH-AFFINITY; RO; 04-6790; ANTAGONISTS;
D O I
10.1016/B978-0-12-384976-2.00001-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:1 / 34
页数:34
相关论文
共 167 条
[1]   Interaction of chiral MS-245 analogs at h5-HT6 receptors [J].
Abate, C ;
Kolanos, R ;
Dukat, M ;
Setola, V ;
Roth, BL ;
Glennon, RA .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (15) :3510-3513
[2]   Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists [J].
Ahmed, M ;
Briggs, MA ;
Bromidge, SM ;
Buck, T ;
Campbell, L ;
Deeks, NJ ;
Garner, A ;
Gordon, L ;
Hamprecht, DW ;
Holland, V ;
Johnson, CN ;
Medhurst, AD ;
Mitchell, DJ ;
Moss, SF ;
Powles, J ;
Seal, JT ;
Stean, TO ;
Stemp, G ;
Thompson, M ;
Trail, B ;
Upton, N ;
Winborn, K ;
Witty, DR .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (21) :4867-4871
[3]  
Ahmed M., 2003, Patent No. [2003080580A2, 2003080580]
[4]  
AHMED M, 2005, Patent No. 2005095346
[5]  
AHMED M, 2007, Patent No. 2007039219
[6]   Indene-Based Scaffolds. 2. An Indole-Indene Switch: Discovery of Novel Indenylsulfonamides as 5-HT6 Serotonin Receptor Agonists [J].
Alcalde, Ermitas ;
Mesquida, Neus ;
Lopez-Perez, Sara ;
Frigola, Jordi ;
Merce, Ramon .
JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (03) :675-687
[7]  
[Anonymous], [No title captured]
[8]  
[Anonymous], [No title captured], Patent No. 941994
[9]   Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats [J].
Arnt, Jorn ;
Bang-Andersen, Benny ;
Grayson, Ben ;
Bymaster, Franklin P. ;
Cohen, Michael P. ;
DeLapp, Neil W. ;
Giethlen, Bruno ;
Kreilgaard, Mads ;
McKinzie, David L. ;
Neill, Joanna C. ;
Nelson, David L. ;
Nielsen, Soren M. ;
Poulsen, Mette N. ;
Schaus, John M. ;
Witten, Louise M. .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2010, 13 (08) :1021-1033
[10]  
Becker O., 2006, Preparation of Piperazinylarylamines as 5-HT6 Modulators, Patent No. [2006081332, WO/2006081332]