The transcriptional regulatory repertoire of Corynebacterium glutamicum: Reconstruction of the network controlling pathways involved in lysine and glutamate production

被引:25
作者
Brinkrolf, Karina [1 ]
Schroeder, Jasmin [1 ]
Puehler, Alfred [1 ]
Tauch, Andreas [1 ]
机构
[1] Univ Bielefeld, Ctr Biotechnol, Inst Genomforsch & Syst Biol, D-33615 Bielefeld, Germany
关键词
Corynebacterium glutamicum; Transcription regulation; Transcriptional regulatory network; Glutamate biosynthesis; Lysine biosynthesis; Systems biology; GLOBAL EXPRESSION CHANGES; ESCHERICHIA-COLI K-12; DNA-BINDING SITES; SIGMA-FACTOR SIGB; QUINONE OXIDOREDUCTASE; 2-COMPONENT SYSTEM; BACILLUS-SUBTILIS; OXIDATIVE STRESS; GENE-EXPRESSION; NAD METABOLISM;
D O I
10.1016/j.jbiotec.2009.12.004
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Corynebacterium glutamicum is one of the best studied organisms of the high G+C branch of Gram-positive bacteria and an emerging model system for the suborder Corynebacterineae. To gain insights into the regulatory gene composition and architecture of the transcriptional regulatory network of C. glutamicum, components of the transcriptional regulatory repertoire were intensively studied by many scientific groups in recent years. In this mini-review, we summarize the present knowledge about the deduced transcriptional regulatory repertoire of C. glutamicum and the current status of transcriptional regulatory network reconstruction with regard to the genome-wide detection of transcriptional regulations, coregulatory interactions and hierarchical cross-regulations. Moreover, we provide an overview of those regulators and their transcriptional regulations controlling genes involved in the conversion of the carbon sources glucose, fructose and sucrose into the industrially relevant products L-lysine and L-glutamate. This data will contribute to our understanding of L-lysine and L-glutamate production by C glutamicum from the perspective of systems biology and may provide the basis for computational modeling of the respective biotechnologically important metabolic pathways. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:173 / 182
页数:10
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