Zebrafish: An Emerging Model for Orthopedic Research

被引：62

作者：

Busse, Bjoern ^{[1
]}

Galloway, Jenna L. ^{[2
]}

Gray, Ryan S. ^{[3
]}

Harris, Matthew P. ^{[4
]}

Kwon, Ronald Y. ^{[5
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Osteol & Biomech, D-22529 Hamburg, Germany

[2] Harvard Med Sch, Massachusetts Gen Hosp, Harvard Stem Cell Inst, Dept Orthopaed Surg,Ctr Regenerat Med, 185 Cambridge St, Boston, MA 02114 USA

[3] Univ Texas Austin, Dell Med Sch, Dell Pediat Res Inst, Dept Pediat, Austin, TX 78712 USA

[4] Harvard Med Sch, Boston Childrens Hosp, Dept Orthoped Res, Dept Genet, 300 Longwood Ave, Boston, MA 02115 USA

[5] Univ Washington, Dept Mech Engn, Inst Stem Cell & Regenerat Med, Dept Orthopaed & Sports Med, Seattle, WA 98195 USA

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 2020年 / 38卷 / 05期

基金：

美国国家卫生研究院;

关键词：

zebrafish; bone; tendon; muscle; cartilage; DANIO-RERIO OSTARIOPHYSI; BRANCHIAL ARCH MUTANTS; IDIOPATHIC SCOLIOSIS; CRANIOFACIAL DEVELOPMENT; TRANSCRIPTION FACTORS; TENDON PROGENITORS; BONE REGENERATION; TISSUE-REPAIR; GENE; FIN;

D O I：

10.1002/jor.24539

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Advances in next-generation sequencing have transformed our ability to identify genetic variants associated with clinical disorders of the musculoskeletal system. However, the means to functionally validate and analyze the physiological repercussions of genetic variation have lagged behind the rate of genetic discovery. The zebrafish provides an efficient model to leverage genetic analysis in an in vivo context. Its utility for orthopedic research is becoming evident in regard to both candidate gene validation as well as therapeutic discovery in tissues such as bone, tendon, muscle, and cartilage. With the development of new genetic and analytical tools to better assay aspects of skeletal tissue morphology, mineralization, composition, and biomechanics, researchers are emboldened to systematically approach how the skeleton develops and to identify the root causes, and potential treatments, of skeletal disease. (c) 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J. Orthop. Res

引用

页码：925 / 936

页数：12

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