The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction

被引：5
作者：
Finn-Sell, Sarah L. [1 ]
Renshall, Lewis J. [1 ]
Cowley, Elizabeth J. [1 ]
Dilworth, Mark R. [1 ]
Wareing, Mark [1 ]
Greenwood, Susan L. [1 ]
Sibley, Colin P. [1 ]
Cottrell, Elizabeth C. [1 ]
机构：
[1] Univ Manchester, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Maternal & Fetal Hlth Res Ctr,Inst Human Dev, Manchester M13 0JH, Lancs, England
来源：
PLACENTA | 2016年 / 42卷
关键词：
Pre-eclampsia; Fetal growth restriction; Atrial natriuretic peptide; Mouse; BLOOD-PRESSURE; TROPHOBLAST INVASION; ENOS-KNOCKOUT; MICE; HYPERTENSION; PATHOPHYSIOLOGY; MANAGEMENT; PREGNANCY;
D O I：
10.1016/j.placenta.2016.04.003
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP(+)/(+)), heterozygous (ANP(+/-)) and knockout (ANP(-/-)) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP(-/-) versus ANP(+/+) mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
引用
收藏
页码：25 / 27
页数：3
相关论文
共 50 条
[41]   Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis [J].
Dudding, T. ;
Heron, J. ;
Thakkinstian, A. ;
Nurk, E. ;
Golding, J. ;
Pembrey, M. ;
Ring, S. M. ;
Attia, J. ;
Scott, R. J. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (11) :1868-1875
[42]   N-terminal pro B-type natriuretic peptide as biomarker to predict pre-eclampsia and maternal-fetal complications [J].
Nan, M. N. ;
Garrido-Gimenez, C. ;
Garcia-Osuna, A. ;
Manau, P. Garcia ;
Ullmo, J. ;
Mora, J. ;
Sanchez-Garcia, O. ;
Platero, J. ;
Cruz-Lemini, M. ;
Llurba, E. ;
EuroPE Working Grp .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2025, 65 (04) :447-455
[43]   Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia [J].
Whitehead, C. L. ;
Walker, S. P. ;
Lappas, M. ;
Tong, S. .
JOURNAL OF PERINATOLOGY, 2013, 33 (08) :600-604
[44]   Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia [J].
C L Whitehead ;
S P Walker ;
M Lappas ;
S Tong .
Journal of Perinatology, 2013, 33 :600-604
[45]   Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction [J].
Egbor, M ;
Ansari, T ;
Morris, N ;
Green, CJ ;
Sibbons, PD .
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2006, 113 (05) :580-589
[46]   Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction [J].
Haruki Nishizawa ;
Sayuri Ota ;
Machiko Suzuki ;
Takema Kato ;
Takao Sekiya ;
Hiroki Kurahashi ;
Yasuhiro Udagawa .
Reproductive Biology and Endocrinology, 9
[47]   Abnormal placental CD8+T-cell infiltration is a feature of fetal growth restriction and pre-eclampsia [J].
Lager, Susanne ;
Sovio, Ulla ;
Eddershaw, Elizabeth ;
van der Linden, Margaretha W. ;
Yazar, Cansu ;
Cook, Emma ;
Happerfield, Lisa ;
Jessop, Flora A. ;
Sebire, Neil J. ;
Charnock-Jones, D. Stephen ;
Smith, Gordon C. S. .
JOURNAL OF PHYSIOLOGY-LONDON, 2020, 598 (23) :5555-5571
[48]   Doppler assessment of the uterine circulation in the second trimester in twin pregnancies: prediction of pre-eclampsia, fetal growth restriction and birth weight discordance [J].
Geipel, A ;
Berg, C ;
Germer, U ;
Katalinic, A ;
Krapp, M ;
Smrcek, J ;
Gembruch, U .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2002, 20 (06) :541-545
[49]   Sex-hormone binding globulin (SHBG) levels during pregnancy as predictors for pre-eclampsia and fetal growth restriction [J].
Valdes R, Enrique ;
Lattes A, Karina ;
Munoz S, Hernan ;
Angel Cumsille, Miguel .
REVISTA MEDICA DE CHILE, 2012, 140 (05) :589-594
[50]   DIFFERENTIAL EXPRESSION OF PLACENTAL ENDOTHELIAL CELL-SPECIFIC HOMEOBOX GENE HEX IS ASSOCIATED WITH ABNORMAL ANGIOGENESIS IN FETAL GROWTH RESTRICTION AND PRE-ECLAMPSIA [J].
Murthi, P. ;
Rajaraman, G. ;
Pathirage, N. A. ;
Keogh, R. J. ;
Badet, J. ;
Gude, N. .
PLACENTA, 2010, 31 (09) :A38-A38
12345