How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

被引：7

作者：

Rodrigues, Renata Miranda ^{[1
]}

Bernardo, Vagner Goncalves ^{[2
]}

Da Silva, Sabrina Daniela ^{[3
,4
]}

Camisasca, Danielle Resende ^{[5
]}

de Silvestre Faria, Paulo Antonio ^{[6
]}

Dias, Fernando Luiz ^{[7
]}

Ribeiro Pinto, Luis Felipe ^{[8
]}

Albano, Rodolpho Mattos ^{[2
]}

Bergmann, Anke ^{[8
]}

Chaves Lourenco, Simone de Queiroz ^{[1
]}

机构：

[1] Univ Fed Fluminense, Programa Grad Odontol, Niteroi, RJ, Brazil

[2] Univ Estado Rio De Janeiro, Rio De Janeiro, RJ, Brazil

[3] Lady Davis Inst Med Res, Segal Canc Ctr, Dept Otolaryngol Head & Neck Surg, Montreal, PQ, Canada

[4] Lady Davis Inst Med Res, Sir Mortimer B Davis Jewish Gen Hosp, Montreal, PQ, Canada

[5] Univ Fed Espirito Santo, Dept Patol Oral, Vitoria, ES, Brazil

[6] Inst Nacl Canc INCA, Div Patol, Rio De Janeiro, RJ, Brazil

[7] Inst Nacl Canc INCA, Dept Cirurgia Cabeca & Pescoco, Rio De Janeiro, RJ, Brazil

[8] Inst Nacl Canc INCA, Ctr Pesquisas, Programa Carcinogenese Mol, Rio De Janeiro, RJ, Brazil

来源：

JOURNAL OF APPLIED ORAL SCIENCE | 2020年 / 28卷

关键词：

Oral cancer; Squamous cell carcinoma; Prognosis; Survival; Oral pathology; GRADING SYSTEMS; ORAL TONGUE; SURVIVAL; STAGE; INVASION; CANCER; CLASSIFICATION; EXPRESSION;

D O I：

10.1590/1678-7757-2019-0198

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. Objective: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). Methodology: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). Results: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. Conclusion: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.

引用

页数：7

共 32 条

[1]

Altman DG, 2012, BMC MED, V10, DOI [10.1186/1741-7015-10-51, 10.1371/journal.pmed.1001216]

[2]

Amit M, 2018, HEAD NECK-J SCI SPEC, P1

[3]

BARASCH A, 1994, CANCER, V73, P509, DOI 10.1002/1097-0142(19940201)73:3<509::AID-CNCR2820730303>3.0.CO

[4]

2-X

[5] Prognostic and predictive factors in oral squamous cell cancer:: important tools for planning individual therapy? [J].

Bettendorf, O ;

Piffkò, J ;

Bànkfalvi, A .

ORAL ONCOLOGY, 2004, 40 (02) :110-119

[6] Tumour budding activity and cell nest size determine patient outcome in oral squamous cell carcinoma: proposal for an adjusted grading system [J].

Boxberg, Melanie ;

Jesinghaus, Moritz ;

Dorfner, Christiane ;

Mogler, Carolin ;

Drecoll, Enken ;

Warth, Arne ;

Steiger, Katja ;

Bollwein, Christine ;

Meyer, Petra ;

Wolff, Klaus D. ;

Kolk, Andreas ;

Weichert, Wilko .

HISTOPATHOLOGY, 2017, 70 (07) :1125-1137

[7]

Brandwein-Gensler A, 2005, AM J SURG PATHOL, V29, P167

[8] Validation of the Histologic Risk Model in a New Cohort of Patients With Head and Neck Squamous Cell Carcinoma [J].

Brandwein-Gensler, Margaret ;

Smith, Richard V. ;

Wang, Beverly ;

Penner, Carla ;

Theilken, Andrea ;

Broughel, Darcy ;

Schiff, Bradley ;

Owen, Randall P. ;

Smith, Jonathan ;

Sarta, Cathy ;

Hebert, Tiffany ;

Nason, Rick ;

Ramer, Marie ;

DeLacure, Mark ;

Hirsch, David ;

Myssiorek, David ;

Heller, Keith ;

Prystowsky, Michael ;

Schlecht, Nicolas F. ;

Negassa, Abdissa .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2010, 34 (05) :676-688

[9]

Brasil. Ministerio da Saude, 2018, EST

[10] Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma [J].

Camisasca, Danielle Resende ;

Honorato, Julia ;

Bernardo, Vagner ;

da Silva, Licinio Esmeraldo ;

da Fonseca, Eliene Carvalho ;

Silvestre de Faria, Paulo Antonio ;

Dias, Fernando Luiz ;

Chaves Lourenco, Simone de Queiroz .

ORAL ONCOLOGY, 2009, 45 (03) :225-233

← 1 2 3 4 →