Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies

被引：229

作者：

Furue, Masutaka ^{[1
,2
,3
]}

Chiba, Takahito ^{[1
]}

Tsuji, Gaku ^{[1
,2
]}

Ulzii, Dugarmaa ^{[1
]}

Kido-Nakahara, Makiko ^{[1
]}

Nakahara, Takeshi ^{[1
,3
]}

Kadono, Takafumi ^{[4
]}

机构：

[1] Kyushu Univ, Dept Dermatol, Fukuoka, Japan

[2] Kyushu Univ, Res & Clin Ctr Yusho & Dioxin, Fukuoka, Japan

[3] Kyushu Univ, Div Skin Surface Sensing, Dept Dermatol, Fukuoka, Japan

[4] St Marianna Univ, Dept Dermatol, Sch Med, Kawasaki, Kanagawa, Japan

来源：

ALLERGOLOGY INTERNATIONAL | 2017年 / 66卷 / 03期

关键词：

Atopic dermatitis; Filaggrin; IgE autoreactivity; Th2; Th22; GENOME-WIDE ASSOCIATION; ARYL-HYDROCARBON RECEPTOR; PHOSPHODIESTERASE-4; PDE4; INHIBITOR; MANGANESE SUPEROXIDE-DISMUTASE; ACTIVATION-REGULATED CHEMOKINE; SKIN BARRIER; SERUM IGE; SUSCEPTIBILITY LOCI; LANGERHANS CELLS; CLINICAL-TRIAL;

D O I：

10.1016/j.alit.2016.12.002

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression. The lesional skin of AD exhibits Th2- and Th22-deviated immune reactions that are progressive during disease chronicity. Th2 and Th22 cytokines further deteriorate the skin barrier by inhibiting filaggrin expression. Some IgEs are reactive to self-antigens. The IgE autoreactivity may precipitate the chronicity of AD. Upon activation of the ORAI1 calcium channel, atopic epidermis releases large amounts of thymic stromal lymphopoietin (TSLP), which initiates the Th2 and Th22 immune response. Th2-derived interleukin-31 and TSLP induce an itch sensation. Taken together, TSLP/Th2/Th22 pathway is a promising target for developing new therapeutics for AD. Enhancing filaggrin expression using ligands for the aryl hydrocarbon receptor may also be an adjunctive measure to restore the disrupted barrier function specifically for AD. Copyright (C) 2016, Japanese Society of Allergology. Production and hosting by Elsevier B.V.

引用

页码：398 / 403

页数：6

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