The RIP kinases: crucial integrators of cellular stress

被引:311
作者
Meylan, E [1 ]
Tschopp, J [1 ]
机构
[1] Univ Lausanne, Dept Biochem, BIL Biomed Res Ctr, CH-1066 Epalinges, Switzerland
关键词
D O I
10.1016/j.tibs.2005.01.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Since the discovery of the first member ten years ago, the receptor-interacting protein (RIP) family kinases have emerged as essential sensors of cellular stress. The different members integrate both extracellular stress signals transmitted by various cell-surface receptors and signals emanating from intracellular stress. The cascades of events initiated by activated RIPs are complex. Not only are pro-survival, inflammatory and immune responses triggered by RIP kinases via the activation of transcription factors such as NF-kappa B and AP-1, but opposing, death-inducing programs can also be initiated by the RIP kinases. Hence, RIP kinases are crucial regulators of cell survival and cell death.
引用
收藏
页码:151 / 159
页数:9
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