New Hydrazides and Hydrazide-Hydrazones of 2,3-Dihalogen Substituted Propionic Acids: Synthesis and invitro Antimicrobial Activity Evaluation

被引：10

作者：

Popiolek, Lukasz ^{[1
]}

Biernasiuk, Anna ^{[2
]}

机构：

[1] Med Univ Lublin, Dept Organ Chem, Fac Pharm, 4A Chodzki St, PL-20093 Lublin, Poland

[2] Med Univ Lublin, Fac Pharm, Dept Pharmaceut Microbiol, 1 Chodzki St, PL-20093 Lublin, Poland

来源：

CHEMISTRY & BIODIVERSITY | 2017年 / 14卷 / 08期

关键词：

Hydrazides; Hydrazide-hydrazone; Condensation reaction; Antimicrobial activity; MIC; DERIVATIVES; MECHANISM; COUMARIN; NITROFURANTOIN; ANTIBACTERIAL; PYRIDINE;

D O I：

10.1002/cbdv.201700075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The main aim of this research was the synthesis, spectral identification and invitro antimicrobial evaluation of new hydrazides and hydrazide-hydrazones of 2,3-dihalogen substituted propionic acids. New hydrazides were obtained by the substitution reaction of appropriate ethyl esters of 2,3-dihalogen substituted propionic acids with hydrazine hydrate. Then obtained hydrazides were subjected to condensation reaction with various aldehydes which yielded with new hydrazide-hydrazone derivatives. All obtained compounds were identified on the basis of spectral methods (H-1-NMR, C-13-NMR) and invitro screened against a panel of bacterial and fungal strains according to EUCAST and CLSI guidelines.

引用

页数：11

共 50 条

[41] Synthesis of substituted 2-ethoxycarbonyl- and 2-carboxyquinoxalin-3-ones for evaluation of antimicrobial and anticancer activity [J].

Sanna, P ;

Carta, A ;

Loriga, M ;

Zanetti, S ;

Sechi, L .

FARMACO, 1998, 53 (07) :455-461

[42] Synthesis and in vitro antimicrobial activity of new 3-(2-morpholinoquinolin-3-yl) substituted acrylonitrile and propanenitrile derivatives [J].

Makawana, Jigar A. ;

Patel, Manish P. ;

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[43] Synthesis and in vitro antimicrobial activity of new 3-(2-morpholinoquinolin-3-yl) substituted acrylonitrile and propanenitrile derivatives [J].

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Ranjan G. Patel .

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[44] Design and synthesis of new N′-substituted-2-methylquinoline-3-carbohydrazides with antioxidant and antimicrobial activity [J].

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Venugopal, Muralidharan ;

Maddela, Rambabu ;

Ajitha, Makula .

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2015, 54 (07) :930-935

[45] Synthesis and Evaluation of Antimicrobial Activity of Some 2-Morpholinomethylamino-4-(7-Unsubstituted/Substituted Coumarin-3-yl)-6-Chlorosubstitutedphenyl Pyrimidines [J].

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Abdou, Amr M. ;

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[49] Studies on synthesis of novel pyrido[2,3-d]pyrimidine derivatives, evaluation of their antimicrobial activity and molecular docking [J].

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