Progress and Prospects in Pediatric Leukemia

被引：47

作者：

Madhusoodhan, P. Pallavi ^{[1
]}

Carroll, William L. ^{[1
]}

Bhatla, Teena ^{[1
]}

机构：

[1] NYU, Div Pediat Hematol Oncol, Dept Pediat, Perlmutter Canc Ctr,Langone Med Ctr, New York, NY USA

来源：

CURRENT PROBLEMS IN PEDIATRIC AND ADOLESCENT HEALTH CARE | 2016年 / 46卷 / 07期

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; CENTRAL-NERVOUS-SYSTEM; WORLD-HEALTH-ORGANIZATION; MINIMAL RESIDUAL DISEASE; CHILDHOOD T-CELL; CLINICAL-FEATURES; RELAPSE RISK; MYELOPROLIFERATIVE DISORDER; MYELOMONOCYTIC LEUKEMIA;

D O I：

10.1016/j.cppeds.2016.04.003

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Pediatric leukemia is the single most common malignancy affecting children, representing up to 30% of all pediatric cancers. Dramatic improvements in survival for acute lymphoblastic leukemia (ALL) have taken place over the past 4 decades with outcomes approaching 90% in the latest studies. However, progress has been slower for myeloid leukemia and certain subgroups like infant ALL, adolescent/young adult ALL, and relapsed ALL. Recent advances include recognition of molecularly defined subgroups, which has ushered in precision medicine approaches. We discuss the current understanding of the biology of the various childhood leukemias, recent advances in research, and future challenges in this field.

引用

页码：229 / 241

页数：13

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