Preparation of novel β-cyclodextrin functionalized monolith and its application in chiral separation

被引：41
作者：
Lv, Yongqin [1 ]
Mei, Danping [1 ]
Pan, Xinxin [1 ]
Tan, Tianwei [1 ]
机构：
[1] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2010年 / 878卷 / 26期
基金：
中国国家自然科学基金;
关键词：
Ethylenediamine-beta-CD; Poly(GMA-co-EGDMA); Chiral separation; Ibuprofen; CAPILLARY-ELECTROPHORESIS; ENANTIOSELECTIVE SEPARATION; PHARMACEUTICAL FORMULATIONS; MACROPOROUS POLYMERS; CHROMATOGRAPHY; ENANTIOMERS; IBUPROFEN; DERIVATIVES; SELECTOR; PLASMA;
D O I：
10.1016/j.jchromb.2010.07.020
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel beta-cyclodextrin (beta-CD) functionalized organic polymer monolith was prepared by covalently bonding ethylenediamine-beta-CD (EDA-beta-CD) to poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) (poly(CMA-co-ECDMA)) monolith via ring opening reaction of epoxy groups. SEM characterization was performed to confirm the homogeneity of the monolithic polymer. The resulting monolith was then characterized by DSC and XPS elemental analysis to study the thermal stability of the monolith, and to prove the successful immobilization of beta-CD on the polymer substrate. The beta-CD hgand density of 0.68 mmol g(-1) was obtained for the modified monolith, indicating the high reactivity and efficiency of the EDA-beta-CD modifier. The ethylenecliamine-beta-CD functionalized monoliths were used for the chiral separation of ibuprofen racemic mixture and showed promising results. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：2461 / 2464
页数：4
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