Inflammatory Bowel Disease: A Potential Result from the Collusion between Gut Microbiota and Mucosal Immune System

被引：64

作者：

Yue, Bei ^{[1
]}

Luo, Xiaoping ^{[1
]}

Yu, Zhilun ^{[1
]}

Mani, Sridhar ^{[2
,3
]}

Wang, Zhengtao ^{[1
]}

Dou, Wei ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med SHUTCM, Inst Chinese Mat Med, Shanghai Key Lab Formulated Chinese Med, Shanghai 201203, Peoples R China

[2] Albert Einstein Coll Med, Dept Med, The Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Genet, The Bronx, NY 10461 USA

来源：

MICROORGANISMS | 2019年 / 7卷 / 10期

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

Inflammatory bowel disease; mucosal immune system; gut microbiota; INTESTINAL EPITHELIAL-CELLS; INVASIVE ESCHERICHIA-COLI; REGULATORY T-CELLS; NOD-LIKE RECEPTORS; CROHNS-DISEASE; FECAL MICROBIOTA; REDUCED DIVERSITY; BACTERIAL LIGANDS; CANDIDA-ALBICANS; ENTERIC VIROME;

D O I：

10.3390/microorganisms7100440

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Host health depends on the intestinal homeostasis between the innate/adaptive immune system and the microbiome. Numerous studies suggest that gut microbiota are constantly monitored by the host mucosal immune system, and any slight disturbance in the microbial communities may contribute to intestinal immune disruption and increased susceptibility to inflammatory bowel disease (IBD), a chronic relapsing inflammatory condition of the gastrointestinal tract. Therefore, maintaining intestinal immune homeostasis between microbiota composition and the mucosal immune system is an effective approach to prevent and control IBD. The overall theme of this review is to summarize the research concerning the pathogenesis of IBD, with particular focus on the factors of gut microbiota-mucosal immune interactions in IBD. This is a comprehensive and in-depth report of the crosstalk between gut microbiota and the mucosal immune system in IBD pathogenesis, which may provide insight into the further evaluation of the therapeutic strategies for IBD.

引用

页数：21

共 181 条

[51] Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis [J].

Feller, Martin ;

Huwiler, Karin ;

Stephan, Roger ;

Altpeter, Ekkehardt ;

Shang, Aijing ;

Furrer, Hansjakob ;

Pfyffer, Gaby E. ;

Jemmi, Thomas ;

Baumgartner, Andreas ;

Egger, Matthias .

LANCET INFECTIOUS DISEASES, 2007, 7 (09) :607-613

[52] Genes, diet and inflammatory bowel disease [J].

Ferguson, Lynnette R. ;

Shelling, Andrew N. ;

Browning, Brian L. ;

Huebner, Claudia ;

Petermann, Ivonne .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2007, 622 (1-2) :70-83

[53] NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense [J].

Franchi, Luigi ;

Kamada, Nobuhiko ;

Nakamura, Yuumi ;

Burberry, Aaron ;

Kuffa, Peter ;

Suzuki, Shiho ;

Shaw, Michael H. ;

Kim, Yun-Gi ;

Nunez, Gabriel .

NATURE IMMUNOLOGY, 2012, 13 (05) :449-U45

[54] Sensing and reacting to microbes through the inflammasomes [J].

Franchi, Luigi ;

Munoz-Planillo, Raul ;

Nunez, Gabriel .

NATURE IMMUNOLOGY, 2012, 13 (04) :325-332

[55] Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages [J].

Franchi, Luigi ;

Amer, Amal ;

Body-Malapel, Mathilde ;

Kanneganti, Thirumala-Devi ;

Ozoren, Nesrin ;

Jagirdar, Rajesh ;

Inohara, Naohiro ;

Vandenabeele, Peter ;

Bertin, John ;

Coyle, Anthony ;

Grant, Ethan P. ;

Nunez, Gabriel .

NATURE IMMUNOLOGY, 2006, 7 (06) :576-582

[56] Disease Phenotype and Genotype Are Associated with Shifts in Intestinal-associated Microbiota in Inflammatory Bowel Diseases [J].

Frank, Daniel N. ;

Robertson, Charles E. ;

Hamm, Christina M. ;

Kpadeh, Zegbeh ;

Zhang, Tianyi ;

Chen, Hongyan ;

Zhu, Wei ;

Sartor, R. Balfour ;

Boedeker, Edgar C. ;

Harpaz, Noam ;

Pace, Norman R. ;

Li, Ellen .

INFLAMMATORY BOWEL DISEASES, 2011, 17 (01) :179-184

[57] Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response [J].

Gao, Xinghua ;

Cao, Qiuhua ;

Cheng, Yan ;

Zhao, Dandan ;

Wang, Zhuo ;

Yang, Hongbao ;

Wu, Qijin ;

You, Linjun ;

Wang, Yue ;

Lin, Yanting ;

Li, Xianjing ;

Wang, Yun ;

Bian, Jin-Song ;

Sun, Dongdong ;

Kong, Lingyi ;

Birnbaumer, Lutz ;

Yang, Yong .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (13) :E2960-E2969

[58] Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium [J].

Gerbe, Francois ;

van Es, Johan H. ;

Makrini, Leila ;

Brulin, Benedicte ;

Mellitzer, Georg ;

Robine, Sylvie ;

Romagnolo, Beatrice ;

Shroyer, Noah F. ;

Bourgaux, Jean-Francois ;

Pignodel, Christine ;

Clevers, Hans ;

Jay, Philippe .

JOURNAL OF CELL BIOLOGY, 2011, 192 (05) :767-780

[59] Innate and adaptive immunity in inflammatory bowel disease [J].

Geremia, Alessandra ;

Biancheri, Paolo ;

Allan, Philip ;

Corazza, Gino R. ;

Di Sabatino, Antonio .

AUTOIMMUNITY REVIEWS, 2014, 13 (01) :3-10

[60] Mining the Human Gut Microbiota for Immunomodulatory Organisms [J].

Geva-Zatorsky, Naama ;

Sefik, Esen ;

Kua, Lindsay ;

Pasman, Lesley ;

Tan, Tze Guan ;

Ortiz-Lopez, Adriana ;

Yanortsang, Tsering Bakto ;

Yang, Liang ;

Jupp, Ray ;

Mathis, Diane ;

Benoist, Christophe ;

Kasper, Dennis L. .

CELL, 2017, 168 (05) :928-+

← 1 2 3 4 5 6 7 8 9 10 →