VIVID interacts with the WHITE COLLAR complex and FREQUENCY-interacting RNA helicase to alter light and clock responses in Neurospora

被引:79
作者
Hunt, Suzanne M. [1 ]
Thompson, Seona [1 ]
Elvin, Mark [1 ]
Heintzen, Christian [1 ]
机构
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
基金
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词
blue light; entrainment; photoreceptor; phase; circadian; CIRCADIAN CLOCK; FEEDBACK LOOP; TRANSCRIPTION; PHOSPHORYLATION; BINDING; CRASSA; GENE; PHOTORECEPTOR; ENTRAINMENT; ADAPTATION;
D O I
10.1073/pnas.1009474107
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The photoreceptor and PAS/LOV protein VIVID (VVD) modulates blue-light signaling and influences light and temperature responses of the circadian clock in Neurospora crassa. One of the main actions of VVD on the circadian clock is to influence circadian clock phase by regulating levels of the transcripts encoded by the central clock gene frequency (frq). How this regulation is achieved is unknown. Here we show that VVD interacts with complexes central for circadian clock and blue-light signaling, namely the WHITE-COLLAR complex (WCC) and FREQUENCY-interacting RNA helicase (FRH), a component that complexes with FRQ to mediate negative feedback control in Neurospora. VVD interacts with FRH in the absence of WCC and FRQ but does not seem to control the exosome-mediated negative feedback loop. Instead, VVD acts to modulate the transcriptional activity of the WCC.
引用
收藏
页码:16709 / 16714
页数:6
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