Biologics for chronic rhinosinusitis with nasal polyps: Economics and ethics

被引：12

作者：

Roland, Lauren T. ^{[1
]}

Regenberg, Alan ^{[2
]}

Luong, Amber U. ^{[3
]}

Wise, Sarah K. ^{[4
]}

Toskala, Elina ^{[5
]}

Lam, Kent K. ^{[6
]}

Levy, Joshua M. ^{[4
]}

Franzese, Christine B. ^{[7
]}

Smith, Kristine ^{[8
]}

Kim, Jean ^{[9
]}

机构：

[1] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA

[2] Johns Hopkins Univ, Berman Inst Bioeth, Baltimore, MD USA

[3] Univ Texas Hlth Sci Ctr Houston, Dept Otolaryngol Head & Neck Surg, McGovern Med Sch, Houston, TX 77030 USA

[4] Emory Univ, Dept Otolaryngol Head & Neck Surg, Atlanta, GA 30322 USA

[5] Thomas Jefferson Univ, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19107 USA

[6] Eastern Virginia Med Sch, Dept Otolaryngol Head & Neck Surg, Norfolk, VA 23501 USA

[7] Univ Missouri, Dept Otolaryngol Head & Neck Surg, Columbia, MO USA

[8] Univ Manitoba, Dept Otolaryngol Head & Neck Surg, Winnipeg, MB, Canada

[9] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, 4940 Eastern Ave, Baltimore, MD 21224 USA

来源：

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY | 2021年 / 11卷 / 11期

关键词：

chronic rhinosinusitis; medical therapy of chronic rhinosinusitis; rhinosinusitis; ENDOTYPES; OUTCOMES; ASTHMA;

D O I：

10.1002/alr.22864

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Biologics have recently been approved for use in chronic rhinosinusitis with nasal polyps patients. While effective in controlling disease on subjective and objective short-term outcome measures, limited data suggest that biologics have the potential to be used long term. The current wholesale acquisition costs for biologics are quite high. Widespread, prolonged use of these medications may create a large burden to our healthcare system. Cost-effectiveness analyses, particularly for specific patient cohorts, are needed to determine appropriate use of these medications. The ethics of patient preference of various treatment options, counseling regarding side effect profiles, and healthcare economics also need to be addressed.

引用

页码：1524 / 1528

页数：5

共 23 条

[1] Cost-effectiveness and comparative effectiveness of biologic therapy for asthma To biologic or not to biologic? [J].

Anderson, William C., III ;

Szefler, Stanley J. .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2019, 122 (04) :367-372

[2]

[Anonymous], 2011, HYPEREXPENSIVE TREAT

[3]

Bachert C, 2020, J ALLER CL IMM-PRACT, V8, P1514, DOI 10.1016/j.jaip.2020.03.007

[4] Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials [J].

Bachert, Claus ;

Han, Joseph K. ;

Desrosiers, Martin ;

Hellings, Peter W. ;

Amin, Nikhil ;

Lee, Stella E. ;

Mullol, Joaquim ;

Greos, Leon S. ;

Bosso, John V. ;

Laidlaw, Tanya M. ;

Cervin, Anders U. ;

Maspero, Jorge F. ;

Hopkins, Claire ;

Olze, Heidi ;

Canonica, G. Walter ;

Paggiaro, Pierluigi ;

Cho, Seong H. ;

Fokkens, Wytske J. ;

Fujieda, Shigeharu ;

Zhang, Mei ;

Lu, Xin ;

Fan, Chunpeng ;

Draikiwicz, Steven ;

Kamat, Siddhesh A. ;

Khan, Asif ;

Pirozzi, Gianluca ;

Patel, Naimish ;

Graham, Neil M. H. ;

Ruddy, Marcella ;

Staudinger, Heribert ;

Weinreich, David ;

Stahl, Neil ;

Yancopoulos, George D. ;

Mannent, Leda P. .

LANCET, 2019, 394 (10209) :1638-1650

[5] Endotype-driven care pathways in patients with chronic rhinosinusitis [J].

Bachert, Claus ;

Zhang, Nan ;

Hellings, Peter W. ;

Bousquet, Jean .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018, 141 (05) :1543-1551

[6] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[7] A Critical Look at the Efficacy and Costs of Biologic Therapy for Chronic Rhinosinusitis with Nasal Polyposis [J].

Brown, W. Colby ;

Senior, Brent .

CURRENT ALLERGY AND ASTHMA REPORTS, 2020, 20 (06)

[8] A call for cost-effectiveness analysis for biologic therapies in chronic rhinosinusitis with nasal polyps [J].

Codispoti, Christopher D. ;

Mahdavinia, Mahboobeh .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2019, 123 (03) :232-239

[9] A Review of Classification Schemes for Chronic Rhinosinusitis with Nasal Polyposis Endotypes [J].

Dennis, Steven K. ;

Lam, Kent ;

Luong, Amber .

LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY, 2016, 1 (05) :130-134

[10]

DiStefano Michael J, 2019, AMA J Ethics, V21, pE679, DOI 10.1001/amajethics.2019.679

← 1 2 3 →