Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent

被引：137
作者：
Collen, D
机构：
[1] Catholic Univ Louvain, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium
[2] Katholieke Univ Leuven VIB, Ctr Transgene Technol & Gene, B-3001 Leuven, Belgium
来源：
NATURE MEDICINE | 1998年 / 4卷 / 03期
关键词：
D O I：
10.1038/nm0398-279
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thrombosis, the blockage of blood vessels with dots, can lead to acute myocardial infarction and ischemia stroke both leading causes of death. Other than surgical interventions to remove or by pass the blockage or the generation of collateral vessels to provide a new blood supply, the only treatment available is the administration of thrombolytic agents to dissolve the blood clot. In this review, Desire Callen considers the properties and characteristics of staphylokinase that make it the thrombolytic agent of choice.
引用
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页码：279 / 284
页数：6
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