Risk reduction and survival benefit of prophylactic surgery in BRCA mutation carriers, a systematic review

被引：166

作者：

Ludwig, Kandice K. ^{[1
]}

Neuner, Joan ^{[2
]}

Butler, Annabelle ^{[3
]}

Geurts, Jennifer L. ^{[4
]}

Kong, Amanda L. ^{[3
]}

机构：

[1] Indiana Univ Sch Med, Dept Surg, Carmel, IN USA

[2] Med Coll Wisconsin, Dept Med, Div Gen Internal Med, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Surg, Div Surg Oncol, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Human & Mol Genet Ctr, Milwaukee, WI 53226 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2016年 / 212卷 / 04期

关键词：

BRCA; Risk reducing; Prophylactic; Mastectomy; Oophorectomy; REDUCING SALPINGO-OOPHORECTOMY; BREAST-CANCER RISK; NIPPLE-SPARING MASTECTOMY; PROSPECTIVE COHORT; OVARIAN-CANCER; HEREDITARY BREAST; WOMEN; SURVEILLANCE; EFFICACY; GENES;

D O I：

10.1016/j.amjsurg.2016.06.010

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BACKGROUND: Mutations in BRCA1 or BRCA2 genes results in an elevated risk for developing both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may be faced with questions about surgical risk reduction and survival benefit of prophylactic surgery. METHODS: A systematic literature review was performed using the electronic databases PubMed, OVID MEDLINE, and Scopus comparing prophylactic surgery vs observation with respect to breast and ovarian cancer risk reduction and mortality in BRCA mutation carriers. RESULTS: Bilateral risk-reducing mastectomy provides a 90% to 95% risk reduction in BRCA mutation carriers, although the data do not demonstrate improved mortality. The reduction in ovarian and breast cancer risks using risk-reducing bilateral salpingo-oophorectomy has translated to improvement in survival. CONCLUSIONS: Clinical management of patients at increased risk for breast cancer requires consideration of risk, patient preference, and quality of life. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：660 / 669

页数：10