The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

被引：146

作者：

Du, Hongliang ^{[1
]}

Liu, Mengrui ^{[1
]}

Yang, Xiaoye ^{[1
]}

Zhai, Guangxi ^{[1
]}

机构：

[1] Shandong Univ, Coll Pharmaceut Sci, Jinan 250012, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2015年 / 20卷 / 08期

关键词：

DRUG-DELIVERY; CONTROLLED-RELEASE; IN-VITRO; CARBOXYMETHYL CHITOSAN; ORAL DELIVERY; POLYELECTROLYTE COMPLEXES; NATURAL POLYSACCHARIDES; POLYVINYL PYRROLIDONE; TARGETED DELIVERY; HYDROGEL;

D O I：

10.1016/j.drudis.2015.03.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chitosan, a nontoxic and biocompatible polysaccharide, has been widely explored for the gastrointestinal delivery of drugs, proteins, peptides and genes for different therapeutic purposes. Because a pH gradient exists in the gastrointestinal tract, chitosan-based formulations in response to specific pH conditions, such as the low pH in the stomach and a high pH in the intestine, have been developed as a general strategy for disease diagnosis and therapy. Tailored pH-responsive drug release in the gastrointestinal tract can be achieved with various chitosan-based formulations such as nanoparticles, microspheres, hydrogels and nanocomposites. This review focuses on the most recent development of chitosan-based pH-sensitive formulations for gastrointestinal delivery, covering various types of chitosan-based formulations, their pH-responsive mechanisms and biomedical applications.

引用

页码：1004 / 1011

页数：8

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