Fluorescent detection of heparin by a cationic conjugated polyfluorene probe containing aggregation-induced emission units

被引：40

作者：

Xu, Bowei ^{[1
,2
]}

Wu, Xiaofu ^{[1
]}

Li, Haibo ^{[1
,2
]}

Tong, Hui ^{[1
]}

Wang, Lixiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

POLYMER | 2012年 / 53卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Conjugated polymer; Fluorescent probe; Aggregation-induced emission; INTERPOLYELECTROLYTE COMPLEXES; INDUCED THROMBOCYTOPENIA; CARDIAC-SURGERY; POLYMER; COPOLYMERS; SENSORS; DNA; POLYELECTROLYTES; OXADIAZOLE; CARBAZOLE;

D O I：

10.1016/j.polymer.2011.11.058

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel conjugated cationic polyfluorene containing aminated tetraphenylethene (ATPE) unit is developed as a sensitive and selective fluorescence probe for heparin detection based on the combination of aggregation-induced emissive property of the ATPE units and the FRET process from the blue-emissive polyfluorene segments to the yellow-emissive AWE units. The addition of anionic heparin will lead to the formation of heparin/polymer complexes, and turn on the aggregation-induced yellow emission of the ATPE units. A good linear relationship is found between the yellow emission intensity of the AWE units and the heparin concentrations with a limit of detection of 30 nM in aqueous buffer. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：490 / 494

页数：5

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