Expression of peroxisome proliferator-activated receptor (PPAR)-γ in human lung cancer

被引：0

作者：

Inoue, KI

Kawahito, Y

Tsubouchi, Y

Yamada, R

Kohno, M

Hosokawa, Y

Katoh, D

Bishop-Bailey, D

Hla, T

Sano, H

机构：

[1] Kyoto Prefectural Univ Med, Dept Internal Med 1, Kamigyo Ku, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Dept Surg, Kamigyo Ku, Kyoto 6028566, Japan

[3] Univ Connecticut, Sch Med, Dept Physiol, Ctr Vasc Biol, Farmington, CT 06030 USA

[4] Kyoto Red Cross Hosp, Dept Lab Med & Pathol, Kyoto 6050981, Japan

来源：

ANTICANCER RESEARCH | 2001年 / 21卷 / 4A期

关键词：

peroxisome proliferator-activated receptor-gamma; mRNA; protein; lung cancer;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The peroxisome proliferator-activated receptor (PPAR)-gamma is a member of the steroid nuclear receptors. Recent studies have demonstrated that PPAR-gamma is expressed in several cancer cells. We examined the PPAR-gamma expression in both normal lung and major types of human lung cancer. The expression of PPAR-gamma mRNA was detected in 2 out of 3 normal lung tissues and its protein was detected in 3 out of 5 normal lung tissues. In contrast, a small cell carcinoma cell line and all other types of lung cancer tissues expressed PPAR-gamma mRNA and its protein. Immunoreactive PPAR-gamma is strongly expressed in cancer cells and moderately in mononuclear cells, endothelial cells and fibroblasts of lung cancer tissues. Our results suggest that PPAR-gamma may play an important role in the pathogenesis and/or progression of lung cancer, and may be a novel therapeutical target for therapy of lung cancer.

引用

页码：2471 / 2476

页数：6

共 25 条

[1] Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans - No alteration in adipose tissue of obese and NIDDM patients [J].