A dendritic nano-sized hexanuclear ruthenium(II) complex as a one- and two-photon luminescent tracking non-viral gene vector

被引：24
作者：
Qiu, Kangqiang [1 ]
Yu, Bole [1 ]
Huang, Huaiyi [1 ]
Zhang, Pingyu [1 ]
Huang, Juanjuan [1 ]
Zou, Shanshan [1 ]
Chen, Yu [1 ]
Ji, Liangnian [1 ]
Chao, Hui [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China
来源：
SCIENTIFIC REPORTS | 2015年 / 5卷
基金：
美国国家科学基金会;
关键词：
QUANTUM DOTS; DNA CONDENSATION; DELIVERY; TRANSFECTION; PROGRESS; THERAPY; NANOPARTICLES; NANOCRYSTALS; DENDRIMERS; CATALYSIS;
D O I：
10.1038/srep10707
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Fluorescent tracking gene delivery could provide us with a better understanding of the critical steps in the transfection process. However, for in vivo tracking applications, a small diameter (< 10 nm) is one of the rigorous requirements for tracking vectors. Herein, we have demonstrated a new paradigm for two-photon tracking gene delivery based on a dendritic nano-sized hexanuclear ruthenium(II) polypyridyl complex. Because this metallodendrimer has a multivalent periphery, the complex, which is 6.1 nm, showed high stability and excellent dispersibility and could stepwise condense DNA in vitro. With the outstanding photochemical properties of Ru(II) polypyridyl, this complex could track gene delivery in vivo using one- and two-photon imaging.
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页数：11
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