Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives

被引：149
作者：
Zhang, Hua [1 ]
Yee, Duglas [1 ]
Wang, Chun [1 ]
机构：
[1] Univ Minnesota, Ctr Canc, Dept Biomed Engn, Minneapolis, MN 55455 USA
来源：
NANOMEDICINE | 2008年 / 3卷 / 01期
关键词：
bioconjugation; cancer; metastasis; quantum dots; sentinel lymph nodes; targeted therapy;
D O I：
10.2217/17435889.3.1.83
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Quantum dots (QDs) are semiconductor nanocrystals that emit fluorescence on excitation with a light source. They have excellent optical properties, including high brightness, resistance to photobleaching and tunable wavelength. Recent developments in surface modification of QDs enable their potential application in cancer imaging. QDs with near-infrared emission could be applied to sentinel lymph-node mapping to aid biopsy and surgery. Conjugation of QDs with biomolecules, including pepticles and antibodies, could be used to target tumors in vivo. In this review, we summarize recent progress in developing QDs for cancer diagnosis and treatment from a clinical standpoint and discuss future prospects of further improving QD technology to identify metastatic cancer cells, quantitatively measure the level of specific molecular targets and guide targeted cancer therapy by providing biodynamic markers for target inhibition.
引用
收藏
页码：83 / 91
页数：9
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