The Use of Stem Cells in Burn Wound Healing: A Review

被引：69

作者：

Ghieh, Fadi ^{[1
]}

Jurjus, Rosalyn ^{[2
]}

Ibrahim, Amir ^{[3
]}

Geagea, Alice Gerges ^{[4
]}

Daouk, Hisham ^{[5
]}

El Baba, Bassel ^{[5
]}

Chams, Sana ^{[5
]}

Matar, Michel ^{[4
]}

Zein, Wadih ^{[6
]}

Jurjus, Abdo ^{[5
]}

机构：

[1] Amer Univ Beirut, Fac Med, Beirut, Lebanon

[2] George Washington Univ, Dept Anat & Regenerat Biol, Washington, DC USA

[3] Amer Univ Beirut, Dept Surg, Beirut, Lebanon

[4] Lebanese Hlth Soc, Beirut, Lebanon

[5] Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol, Beirut, Lebanon

[6] NIH, Inst Eye, Bethesda, MD 20892 USA

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

LIMBAL EPITHELIAL TRANSPLANTATION; ENDOTHELIAL PROGENITOR CELLS; CLINICAL-OUTCOMES; GROWTH-FACTOR; SKIN INJURY; REPAIR; PROMOTES; SURFACE; REGENERATION; KERATINOCYTES;

D O I：

10.1155/2015/684084

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stemcells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated.

引用

页数：9

共 86 条

[71] The Effects of Rat Mesenchymal Stem Cells on Injury Progression In a Rat Model [J].