Xyloketal F:: A strong L-calcium channel blocker from the mangrove fungus Xylaria sp (#2508) from the South China Sea coast

被引：70

作者：

Wu, XY ^{[1
]}

Liu, XH

Lin, YC

Luo, JH

She, ZG

Li, HJ

Chan, WL

Antus, S

Kurtan, T

Elsässer, B

Krohn, K

机构：

[1] Zhongshan Univ, Dept Appl Chem, Guangzhou, Peoples R China

[2] Zhongshan Univ, Dept Pharm, Guangzhou, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

[4] Univ Debrecen, Dept Organ Chem, H-4032 Debrecen, Hungary

[5] Univ Gesamthsch Paderborn, Dept Chem, D-33098 Paderborn, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 19期

关键词：

fungal metabolites; Xylaria sp; Xyloketal F; semi synthesis; absolute configuration; quantum-mechanical CD calculation; L-calcium channel blocker;

D O I：

10.1002/ejoc.200500326

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Xyloketal F (1), an unusual metabolite with strong L-calcium channel blocking activity, was isolated from the mangrove endophytic fungus Xylaria sp. (#2508) collected at the South China Sea coast. Its structure was elucidated by spectral and single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the method of quantum-mechanical calculation of CD spectra. Compound 1 was also synthesized by condensation of xyloketal B with formaldehyde. The L-calcium channel blocking activities of xyloketals B, A, and F were determined, and at the same concentration (0.03 mu mol/L), the inhibiting rates were 12.05%, 21.47% and 50.33 % respectively. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

引用

页码：4061 / 4064

页数：4

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