A Novel 6-(2-methyl-2-alkylsubstituted-2H-chromen-6-yl)-amine Derivatives and Pharmacophore Model as 5-Lipoxygenase Inhibitors

被引：4

作者：

Gong, Young-Dae ^{[1
]}

Cheon, Hyae-Gyeong ^{[2
]}

Lee, Taeho ^{[3
]}

Bae, Mi-Seon ^{[1
]}

Kang, Nam Sook ^{[4
]}

机构：

[1] Dongguk Univ, Dept Chem, Ctr Innovat Drug Lib Res, Seoul 100715, South Korea

[2] Gachon Univ Med & Sci, Dept Pharmacol & Pharmaceut Sci, Inchon 406799, South Korea

[3] Kyungpook Natl Univ, Coll Pharm, Taegu 702701, South Korea

[4] Chungnam Natl Univ, Grad Sch New Drug Discovery & Dev, Taejon 305764, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2011年 / 32卷 / 10期

关键词：

6-(2-Methyl-2-alkylsubstituted-2H-chromen-6-yl)-amine derivatives; 5-Lipoxygenase(5-LO); Drug-like core skeleton; Pharmacophore; SOLID-PHASE SYNTHESIS; PARALLEL SYNTHESIS; INFLAMMATION; ASTHMA; LEUKOTRIENE-B4; MEDIATORS; LIBRARY; LINKER; ASSAY;

D O I：

10.5012/bkcs.2011.32.10.3752

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：3752 / 3755

页数：4

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