Distant organ metastasis patterns and prognosis of neuroendocrine cervical carcinoma: a population-based retrospective study

被引：8
作者：
Li, Qing [1 ,2 ]
Yu, Jie [1 ,3 ]
Yi, Hanjie [1 ,2 ]
Lan, Qiongyu [1 ,2 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Dept Oncol, Nanchang, Peoples R China
[2] Jiangxi Key Lab Clin & Translat Canc Res, Nanchang, Peoples R China
[3] Dongguan Tungwah Hosp, Dept Oncol, Dongguan, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
neuroendocrine cervical carcinoma; SEER database; metastasis; prognosis; survival; UTERINE CERVIX; CELL CARCINOMA; SURVIVAL; THERAPY; CANCER; TUMORS;
D O I：
10.3389/fendo.2022.924414
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BackgroundNeuroendocrine carcinoma of the cervix (NECC) is a rare pathological form of cervical cancer. The prognosis of NECC with distant organ metastases is unclear. In our study, the patterns and prognosis of distant organ metastasis of NECC were investigated. MethodsData were obtained from the surveillance epidemiology and end results (SEER) database from 2000 to 2018. Cox regression, Kaplan-Meier and log-rank analyses were conducted. ResultsNECC was prone to single and multi-site metastases. The median overall survival (OS) was greatly decreased in patients with distant metastasis (P < 0.0001). Other characteristics such as age >= 60 years, poorer grade, higher T stage, those without surgery, no radiotherapy, and no chemotherapy were predictors of poor prognosis. ConclusionsMetastasis is an independent prognostic factor for patients with NECC. Surgery, radiotherapy, and chemotherapy give an overall survival advantage for patients with distant organ metastases.
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页数：10
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