Distant organ metastasis patterns and prognosis of neuroendocrine cervical carcinoma: a population-based retrospective study

被引：8
作者：
Li, Qing [1 ,2 ]
Yu, Jie [1 ,3 ]
Yi, Hanjie [1 ,2 ]
Lan, Qiongyu [1 ,2 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Dept Oncol, Nanchang, Peoples R China
[2] Jiangxi Key Lab Clin & Translat Canc Res, Nanchang, Peoples R China
[3] Dongguan Tungwah Hosp, Dept Oncol, Dongguan, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
neuroendocrine cervical carcinoma; SEER database; metastasis; prognosis; survival; UTERINE CERVIX; CELL CARCINOMA; SURVIVAL; THERAPY; CANCER; TUMORS;
D O I：
10.3389/fendo.2022.924414
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BackgroundNeuroendocrine carcinoma of the cervix (NECC) is a rare pathological form of cervical cancer. The prognosis of NECC with distant organ metastases is unclear. In our study, the patterns and prognosis of distant organ metastasis of NECC were investigated. MethodsData were obtained from the surveillance epidemiology and end results (SEER) database from 2000 to 2018. Cox regression, Kaplan-Meier and log-rank analyses were conducted. ResultsNECC was prone to single and multi-site metastases. The median overall survival (OS) was greatly decreased in patients with distant metastasis (P < 0.0001). Other characteristics such as age >= 60 years, poorer grade, higher T stage, those without surgery, no radiotherapy, and no chemotherapy were predictors of poor prognosis. ConclusionsMetastasis is an independent prognostic factor for patients with NECC. Surgery, radiotherapy, and chemotherapy give an overall survival advantage for patients with distant organ metastases.
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页数：10
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共 18 条
[11]   Prognostic factors and optimal therapy for stages I-II neuroendocrine carcinomas of the uterine cervix: A multi-center retrospective study [J].
Ishikawa, Mitsuya ;
Kasamatsu, Takahiro ;
Tsuda, Hitoshi ;
Fukunaga, Masaharu ;
Sakamoto, Atsuhiko ;
Kaku, Tsunehisa ;
Nakanishi, Toru ;
Hasumi, Yoko ;
Iwata, Takashi ;
Baba, Tsukasa ;
Nogawa, Takayoshi ;
Kudaka, Wataru ;
Kaneda, Hiroshi ;
Ono, Shigemitsu ;
Saito, Fumitaka ;
Taniguchi, Yoshimi ;
Okada, Satoshi ;
Mizuno, Mika ;
Onda, Takashi ;
Yaegashi, Nobuo .
GYNECOLOGIC ONCOLOGY, 2018, 148 (01) :139-146
[12]   Recent updates on grading and classification of neuroendocrine tumors [J].
Kim, Joo Young ;
Hong, Seung-Mo ;
Ro, Jae Y. .
ANNALS OF DIAGNOSTIC PATHOLOGY, 2017, 29 :11-16
[13]   Prognostic factors and treatment comparison in small cell neuroendocrine carcinoma of the uterine cervix based on population analyses [J].
Lin, Li-mei ;
Lin, Qin ;
Liu, Jun ;
Chu, Ke-xin ;
Huang, Yun-Xia ;
Zhang, Zong-Kai ;
Li, Tao ;
Dai, Ya-Qing ;
Li, Jin-Luan .
CANCER MEDICINE, 2020, 9 (18) :6524-6532
[14]   Endocrine tumors of the uterine cervix:: incidence, demographics, and survival with comparison to squamous cell carcinoma [J].
McCusker, ME ;
Coté, TR ;
Clegg, LMX ;
Tavassoli, FJ .
GYNECOLOGIC ONCOLOGY, 2003, 88 (03) :333-339
[15]   Brachytherapy should not be omitted when treating locally advanced neuroendocrine cervical cancer with definitive chemoradiation therapy [J].
Robin, Tyler P. ;
Amini, Arya ;
Schefter, Tracey E. ;
Behbakht, Kian ;
Fisher, Christine M. .
BRACHYTHERAPY, 2016, 15 (06) :845-850
[16]   Neuroendocrine carcinoma of the cervix: a systematic review of the literature [J].
Tempfer, Clemens B. ;
Tischoff, Iris ;
Dogan, Askin ;
Hilal, Ziad ;
Schultheis, Beate ;
Kern, Peter ;
Rezniczek, Guenther A. .
BMC CANCER, 2018, 18
[17]   Enhanced efficacy of adjuvant chemotherapy and radiotherapy in selected cases of surgically resected neuroendocrine carcinoma of the uterine cervix [J].
Xie, Sixia ;
Song, Liang ;
Yang, Fan ;
Tang, Chendian ;
Yang, Shaoyan ;
He, Ji ;
Pan, Xiaoling .
MEDICINE, 2017, 96 (11)
[18]   Small cell neuroendocrine carcinoma of the cervix: Analysis of outcome, recurrence pattern and the impact of platinum-based combination chemotherapy [J].
Zivanovic, O. ;
Leitao, M. M., Jr. ;
Park, K. J. ;
Zhao, H. ;
Diaz, J. P. ;
Konner, J. ;
Alektiar, K. ;
Chi, D. S. ;
Abu-Rustum, N. R. ;
Aghajanian, C. .
GYNECOLOGIC ONCOLOGY, 2009, 112 (03) :590-593
12