An assessment of spatial clustering of leukaemias and lymphomas among young people in New Zealand

被引:21
作者
Dockerty, JD
Sharples, KJ
Borman, B
机构
[1] Univ Otago, Dept Prevent & Social Med, Dunedin, New Zealand
[2] Hlth Funding Author, Wellington, New Zealand
关键词
D O I
10.1136/jech.53.3.154
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Study objective-To assess spatial clustering of childhood leukaemias and lymphomas in New Zealand, using a national dataset from a country with no nuclear installations. Design-New Zealand Map Grid coordinates, derived from the birth addresses of cases and controls were used in clustering analyses that applied Cuzick and Edwards' method. Setting-The whole of New Zealand. Participants-The cases were ascertained from the New Zealand Cancer Registry. They were diagnosed with leukaemia or lymphoma at ages 0-14 years during the period 1976 to 1987. For Hodgkin's disease, the age range was extended to include those aged from 0-24 years. The cancer registrations were linked with national birth records, to obtain the birth addresses of the cases. The controls were selected at random from birth records, with matching to cases (1:1) on age and sex. The analyses included 600 cases and 600 controls. Main results-There was no statistically significant spatial clustering for any tumour group overall, including acute lymphoblastic leukaemia, acute nonlymphoblastic leukaemia, other leukaemias, non-Hodgkin's lymphomas, Hodgkin's disease, and all these combined. Significant clustering was found in a subanalysis for one of three age specific subgroups of acute lymphoblastic leukaemia (ages 10-14 years, p=0.003). Conclusion-The subgroup finding may have been real or a chance association, as several comparisons were made. This study found little evidence for spatial clustering of leukaemias or lymphomas in a population with no nuclear installations.
引用
收藏
页码:154 / 158
页数:5
相关论文
共 35 条
[1]   VIRUSES, CLUSTERS AND CLUSTERING OF CHILDHOOD LEUKEMIA - A NEW PERSPECTIVE [J].
ALEXANDER, FE .
EUROPEAN JOURNAL OF CANCER, 1993, 29A (10) :1424-1443
[2]   CASE CLUSTERING, EPSTEIN-BARR-VIRUS REED-STERNBERG CELL STATUS AND HERPES-VIRUS SEROLOGY IN HODGKINS-DISEASE - RESULTS OF A CASE-CONTROL STUDY [J].
ALEXANDER, FE ;
DANIEL, CP ;
ARMSTRONG, AA ;
CLARK, DA ;
ONIONS, DE ;
CARTWRIGHT, RA ;
JARRETT, RF .
EUROPEAN JOURNAL OF CANCER, 1995, 31A (09) :1479-1486
[3]   Spatial clustering of childhood leukaemia:: summary results from the EUROCLUS project [J].
Alexander, FE ;
Boyle, P ;
Carli, PM ;
Coebergh, JW ;
Draper, GJ ;
Ekbom, A ;
Levi, F ;
McKinney, PA ;
McWhirter, W ;
Michaelis, J ;
Peris-Bonet, R ;
Petridou, E ;
Pompe-Kirn, V ;
Plìsko, I ;
Pukkala, E ;
Rahu, M ;
Storm, H ;
Terracini, B ;
Vatten, L ;
Wray, N .
BRITISH JOURNAL OF CANCER, 1998, 77 (05) :818-824
[4]   Clustering of childhood leukaemia in Hong Kong: Association with the childhood peak and common acute lymphoblastic leukaemia and with population mixing [J].
Alexander, FE ;
Chan, LC ;
Lam, TH ;
Yuen, P ;
Leung, NK ;
Ha, SY ;
Yuen, HL ;
Li, CK ;
Lau, YL ;
Greaves, MF .
BRITISH JOURNAL OF CANCER, 1997, 75 (03) :457-463
[5]  
ALEXANDER FE, 1991, INT J CANCER, V48, P10
[6]  
ALEXANDER FE, 1996, IARC SCI PUBL, V135, P1
[7]   DIRECTLY TRANSMITTED INFECTIOUS-DISEASES - CONTROL BY VACCINATION [J].
ANDERSON, RM ;
MAY, RM .
SCIENCE, 1982, 215 (4536) :1053-1060
[8]  
[Anonymous], CANC EPIDEMIOLOGY PR
[9]  
[Anonymous], LEUKEMIAS EPIDEMIOLO
[10]   APPARENT ASSOCIATION BETWEEN BENZENE AND CHILDHOOD LEUKEMIA - METHODOLOGICAL DOUBTS CONCERNING A REPORT BY KNOX [J].
BITHELL, JF ;
DRAPER, GJ .
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 1995, 49 (04) :437-439