What does biologically meaningful mean? A perspective on gene regulatory network validation

被引：41

作者：

Walhout, Albertha J. M. ^{[1
]}

机构：

[1] Univ Massachusetts, Program Gene Funct & Express, Program Mol Med, Sch Med, Worcester, MA 01605 USA

来源：

GENOME BIOLOGY | 2011年 / 12卷 / 04期

关键词：

BHLH TRANSCRIPTION FACTORS; DNA INTERACTION NETWORK; ORFEOME VERSION 1.1; CAENORHABDITIS-ELEGANS; PROTEIN-DNA; MICROARRAY DATA; C-ELEGANS; GENOME; EXPRESSION; BINDING;

D O I：

10.1186/gb-2011-12-4-109

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.

引用

页数：7

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