Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain

被引：20

作者：

Hellwig, Sabine ^{[1
]}

Amtage, Florian ^{[1
]}

机构：

[1] Univ Freiburg, Neurol Univ Klin, Neurozentrum, D-79106 Freiburg, Germany

来源：

EPILEPSY & BEHAVIOR | 2008年 / 13卷 / 02期

关键词：

adverse effect; anticonvulsants; asterixis; epileptic myoclonus; movement disorder; pregabalin; negative cortical myoclonus; neuropathic pain;

D O I：

10.1016/j.yebeh.2008.04.006

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Myoclonus is a well-known side effect of anticonvulsant drugs. Pregabalin is one of the newer drugs approved for the treatment of focal epilepsies. Frequently it is also used to treat chronic pain syndromes. We describe a patient who, after receiving his first dose of pregabalin to relieve neuropathic pain, presented with a negative myoclonus. Clinical aspects and electrophysiological data such as polygraphic studies, electroencephalography, and measurement of somatosensory evoked potentials support the cortical origin of negative myoclonus. Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：418 / 420

页数：3

共 9 条

[1] Myoclonus associated with the use of gabapentin [J].